PMID- 30907214 OWN - NLM STAT- MEDLINE DCOM- 20191226 LR - 20191226 IS - 2168-1813 (Electronic) IS - 2168-1805 (Linking) VI - 53 IP - 1 DP - 2019 Feb TI - Increased use of cross-sectional imaging for follow-up does not improve post-recurrence survival of surgically treated initially localized R.C.C.: results from a European multicenter database (R.E.C.U.R.). PG - 14-20 LID - 10.1080/21681805.2019.1588919 [doi] AB - Objective: Modality and frequency of image-based renal cell carcinoma (R.C.C.) follow-up strategies are based on risk of recurrence. Using the R.E.C.U.R.-database, frequency of imaging was studied in regard to prognostic risk groups. Furthermore, it was investigated whether imaging modality utilized in contemporary follow-up were associated with outcome after detection of recurrence. Moreover, outcome was compared based on whether the assessment of potential curability was a pre-defined set of criteria's (per-protocol) or stated by the investigator. Materials and methods: Consecutive non-metastatic R.C.C. patients (n = 1,612) treated with curative intent at 12 institutes across eight European countries between 2006 and 2011 were included. Leibovich or U.I.S.S. risk group, recurrence characteristics, imaging modality, frequency and survival were recorded. Primary endpoints were overall survival (O.S.) after detection of recurrence and frequency of features associated with favourable outcome (non-symptomatic recurrences and detection within the follow-up-programme). Results: Recurrence occurred in 336 patients. Within low, intermediate and high risk for recurrence groups, the frequency of follow-up imaging was highest in the early phase of follow-up and decreased significantly over time (p < 0.001). However, neither the image modality for detection nor >/= 50% cross-sectional imaging during follow-up were associated with improved O.S. after recurrence. Differences between per protocol and investigator based assessment of curability did not translate into differences in O.S. Conclusions: As expected, the frequency of imaging was highest during early follow-up. Cross-sectional imaging use for detection of recurrences following surgery for localized R.C.C. did not improve O.S. post-recurrence. Prospective studies are needed to determine the value of imaging in follow-up. FAU - Dabestani, Saeed AU - Dabestani S AD - a Department of Clinical Sciences Lund , Lund University, Skane University Hospital , Lund , Sweden. FAU - Beisland, Christian AU - Beisland C AUID- ORCID: 0000-0002-3216-4937 AD - b Department of Urology , Haukeland University Hospital , Bergen , Norway. AD - c Department of Clinical Medicine , University of Bergen , Bergen , Norway. FAU - Stewart, Grant D AU - Stewart GD AD - d Department of Surgery , Academic Urology Group, University of Cambridge , Cambridge , United Kingdom. FAU - Bensalah, Karim AU - Bensalah K AD - e Department of Urology , University of Rennes , Rennes , France. FAU - Gudmundsson, Eirikur AU - Gudmundsson E AD - f Department of Urology , Landspitali University Hospital , Reykjavik , Iceland. FAU - Lam, Thomas B AU - Lam TB AD - g Academic Urology Unit , University of Aberdeen , Aberdeen , United Kingdom. AD - h Department of Urology , Aberdeen Royal Infirmary , Aberdeen , United Kingdom. FAU - Gietzmann, William AU - Gietzmann W AD - g Academic Urology Unit , University of Aberdeen , Aberdeen , United Kingdom. FAU - Zakikhani, Paimaun AU - Zakikhani P AD - h Department of Urology , Aberdeen Royal Infirmary , Aberdeen , United Kingdom. FAU - Marconi, Lorenzo AU - Marconi L AD - i Department of Urology , Coimbra University Hospital , Coimbra , Portugal. FAU - Fernandez-Pello, Sergio AU - Fernandez-Pello S AD - j Department of Urology , Cabuenes University Hospital , Gijon , Spain. FAU - Monagas, Serenella AU - Monagas S AD - k Department of Urology , San Agustin University Hospital , Aviles , Spain. FAU - Williams, Samuel P AU - Williams SP AD - l Medical School , University of Edinburgh , Edinburgh , United Kingdom. FAU - Powles, Thomas AU - Powles T AD - m Barts Cancer Institute , Queen Mary University of London , London , United Kingdom. FAU - Van Werkhoven, Erik AU - Van Werkhoven E AD - n Department of Bioinformatics and Statistics , The Netherlands Cancer Institute , Amsterdam , The Netherlands. FAU - Meijer, Richard AU - Meijer R AD - o Department of Urology , University Medical Center Utrecht , Utrecht , The Netherlands. FAU - Volpe, Alessandro AU - Volpe A AD - p Department of Urology , University of Eastern Piedmont , Novara , Italy. FAU - Staehler, Michael AU - Staehler M AD - q Department of Urology , Klinikum Grosshadern, Ludwig Maximilians University of Munich , Munich , Germany. FAU - Ljungberg, Borje AU - Ljungberg B AD - r Department of Surgical and Perioperative Sciences , Umea University , Umea , Sweden. FAU - Bex, Axel AU - Bex A AD - s Division of Surgical Oncology, Department of Urology , The Netherlands Cancer Institute , Amsterdam , The Netherlands. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20190325 PL - Sweden TA - Scand J Urol JT - Scandinavian journal of urology JID - 101587186 SB - IM MH - Aged MH - Carcinoma, Renal Cell/*diagnostic imaging/*mortality/surgery MH - Databases, Factual MH - Diagnostic Imaging/methods MH - Europe MH - Female MH - Follow-Up Studies MH - Humans MH - Kidney Neoplasms/*diagnostic imaging/*mortality/surgery MH - Male MH - Middle Aged MH - Neoplasm Recurrence, Local/*diagnostic imaging/*mortality MH - Prognosis MH - Retrospective Studies MH - Risk Factors MH - Survival Rate OTO - NOTNLM OT - Renal cell carcinoma OT - follow-up OT - imaging OT - overall survival EDAT- 2019/03/26 06:00 MHDA- 2019/12/27 06:00 CRDT- 2019/03/26 06:00 PHST- 2019/03/26 06:00 [pubmed] PHST- 2019/12/27 06:00 [medline] PHST- 2019/03/26 06:00 [entrez] AID - 10.1080/21681805.2019.1588919 [doi] PST - ppublish SO - Scand J Urol. 2019 Feb;53(1):14-20. doi: 10.1080/21681805.2019.1588919. Epub 2019 Mar 25.