PMID- 30907227
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20211204
IS  - 1555-8576 (Electronic)
IS  - 1538-4047 (Print)
IS  - 1538-4047 (Linking)
VI  - 20
IP  - 6
DP  - 2019
TI  - miR-506 is a YAP1-dependent tumor suppressor in laryngeal squamous cell 
      carcinoma.
PG  - 826-836
LID - 10.1080/15384047.2018.1564569 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) accounts for 95% of laryngeal cancer 
      incidence. Tobacco use has been shown to have a linear association with the 
      development of the disease. While early diagnosis and treatment of LSCC are 
      critical in improving the 5-year survival rate and quality of life, diagnosis of 
      early-stage LSCC remains challenging because of the unapparent symptoms. Here, we 
      report that miR-506, a critical regulator in many types of cancers, is aberrantly 
      suppressed in LSCC patient tissues and cultured cancer cells. This is likely 
      responsible for the enhanced production of YAP1 protein, a transcriptional factor 
      that is well known for its oncogenic roles in LSCC malignancy. Statistical 
      analysis has confirmed that the expression levels of miR-506 and YAP1 are 
      strongly correlated with the malignant statuses of patient tumors. Restoring the 
      expression level of miR-506 in cultured LSCC cells significantly inhibited 
      proliferation, migration and invasion of the cells. The miR-506 and YAP1 
      regulatory network seems to affect at least pathways involved in apoptosis. Our 
      study, for the first time, has demonstrated a tumor suppressive role of miR-506 
      in LSCC. This opens new opportunities for further exploring the molecular details 
      of the development of the disease and thus will facilitate the development of 
      novel diagnosis and therapeutic strategies.
FAU - Gao, Changhui
AU  - Gao C
AD  - a Department of Otolaryngology Head and Neck Surgery , the First Affiliated 
      Hospital of Zhengzhou University , Zhengzhou City , Henan Province , P. R. China.
FAU - Hu, Shousen
AU  - Hu S
AD  - a Department of Otolaryngology Head and Neck Surgery , the First Affiliated 
      Hospital of Zhengzhou University , Zhengzhou City , Henan Province , P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20190325
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (MIRN506 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Adult
MH  - Aged
MH  - Apoptosis/genetics
MH  - Carcinoma, Squamous Cell/*genetics/*metabolism/pathology
MH  - Cell Cycle/genetics
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*genetics/*metabolism/pathology
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Transcription Factors/*metabolism
MH  - YAP-Signaling Proteins
PMC - PMC6606012
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - YAPI
OT  - apoptosis
OT  - invasion
OT  - miR-506
OT  - migration
OT  - proliferation
EDAT- 2019/03/26 06:00
MHDA- 2020/07/28 06:00
PMCR- 2020/03/25
CRDT- 2019/03/26 06:00
PHST- 2019/03/26 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2019/03/26 06:00 [entrez]
PHST- 2020/03/25 00:00 [pmc-release]
AID - 1564569 [pii]
AID - 10.1080/15384047.2018.1564569 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2019;20(6):826-836. doi: 10.1080/15384047.2018.1564569. Epub 
      2019 Mar 25.