PMID- 30908878
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20191127
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 63
IP  - 9
DP  - 2019 May
TI  - Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High-Fat Diet-Induced 
      Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in 
      Gnotobiotic Mice.
PG  - e1800937
LID - 10.1002/mnfr.201800937 [doi]
AB  - SCOPE: Intestinal microbial metabolites from gallotannins (GT), including gallic 
      acid (GA) and pyrogallol (PG), may possess potential anti-obesogenic properties. 
      Lactobacillus plantarum (L. plantarum) found in the intestinal microbiome encodes 
      for enzymatic activities that metabolize GT into GA and PG. Anti-obesogenic 
      activities of orally administered GT in the presence or absence of L. plantarum 
      is examined in gnotobiotic mice fed a high-fat diet (HFD). METHODS AND RESULTS: 
      Germ-free (GF) C57BL/6J mice are divided into three groups, GF control, GF 
      gavaged with GT, and mice colonized with L. plantarum and gavaged with GT. 
      Compared to the control, GT decreases the expressions of lipogenic genes (e.g., 
      fatty acid synthase (FAS)) in epididymal white adipose tissue and increases 
      thermogenic genes (e.g., nuclear factor erythroid-2-like 1 (Nfe2l1)) in 
      interscapular brown adipose tissue. Intestinal colonization with L. plantarum 
      enhances these effects, and mice colonized with L. plantarum exhibit lower levels 
      of tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), 
      leptin and plasma insulin. CONCLUSIONS: Results indicate that GT and L. plantarum 
      reduce HFD-induced inflammation, insulin resistance, and promote thermogenesis in 
      adipose tissue potentially through the activity of GT-metabolizing bacterial 
      enzymes yielding absorbable bioactive GT metabolites. These findings imply the 
      potential role of prebiotic-probiotic interactions in the prevention of 
      diet-induced metabolic disorders.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Fang, Chuo
AU  - Fang C
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Kim, Hyemee
AU  - Kim H
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Yanagisawa, Lora
AU  - Yanagisawa L
AD  - Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, 
      College Station, 77843, TX, USA.
FAU - Bennett, William
AU  - Bennett W
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Sirven, Maritza A
AU  - Sirven MA
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Alaniz, Robert C
AU  - Alaniz RC
AD  - Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, 
      College Station, 77843, TX, USA.
FAU - Talcott, Stephen T
AU  - Talcott ST
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Mertens-Talcott, Susanne U
AU  - Mertens-Talcott SU
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
LA  - eng
GR  - COALS's Nutrition Obesity Strategic Fellowship/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190410
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Hydrolyzable Tannins)
RN  - EC 3.1.1.- (Carboxylic Ester Hydrolases)
RN  - EC 3.1.1.20 (tannase)
RN  - EC 4.1.1.- (Carboxy-Lyases)
SB  - IM
MH  - Adipose Tissue/*drug effects/metabolism
MH  - Adiposity/physiology
MH  - Administration, Oral
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Carboxy-Lyases/metabolism
MH  - Carboxylic Ester Hydrolases/metabolism
MH  - Cytokines/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Germ-Free Life
MH  - Hydrolyzable Tannins/administration & dosage/chemistry/*pharmacology
MH  - *Lactobacillus plantarum/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Mice, Inbred C57BL
MH  - Panniculitis/drug therapy/metabolism
MH  - Probiotics/*pharmacology
MH  - Thermogenesis/*drug effects/physiology
OTO - NOTNLM
OT  - Lactobacillus plantarum
OT  - gallotannins
OT  - gnotobiotic mouse
OT  - obesity
OT  - polyphenols
OT  - thermogenesis
EDAT- 2019/03/26 06:00
MHDA- 2019/11/28 06:00
CRDT- 2019/03/26 06:00
PHST- 2018/09/06 00:00 [received]
PHST- 2018/11/15 00:00 [revised]
PHST- 2019/03/26 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2019/03/26 06:00 [entrez]
AID - 10.1002/mnfr.201800937 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2019 May;63(9):e1800937. doi: 10.1002/mnfr.201800937. Epub 
      2019 Apr 10.