PMID- 30909821 OWN - NLM STAT- MEDLINE DCOM- 20200522 LR - 20200522 IS - 2159-9777 (Electronic) IS - 0279-1072 (Linking) VI - 51 IP - 2 DP - 2019 Apr-Jun TI - Embracing Neurodiversity in Psychedelic Science: A Mixed-Methods Inquiry into the MDMA Experiences of Autistic Adults. PG - 146-154 LID - 10.1080/02791072.2019.1587116 [doi] AB - This exploratory inquiry analyzed subjective experiences autistic adults reported after they took the drug 3,4-methylenedioxymethamphetamine (MDMA), also known as ecstasy, in nonclinical settings. Using a secure, globally available website, this study collected data from participants in 13 countries who were experienced with MDMA (n = 100). A subset of survey respondents (n = 24) were then invited to participate in qualitative interviews. The researcher applied thematic content analysis of interview transcripts to create a comprehensive account of emergent themes. MDMA has well-documented acute effects that promote pro-social attitudes such as caring and trust in neurotypical, or typically developing, populations. Findings from this study suggested that MDMA-assisted therapy may be an effective catalyst in autistic adults for intra- and interpersonal change. In addition, participants reported accounts of lasting transformation and healing from conditions such as trauma and social anxiety that are common in autistic populations. No participants reported long-term adverse outcomes as a result of using MDMA/ecstasy. Qualitative findings support a case for future clinical trials of MDMA-assisted therapy with autistic adults who present with social adaptability challenges. FAU - Danforth, Alicia L AU - Danforth AL AD - a Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center , Torrance , CA , USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190325 PL - United States TA - J Psychoactive Drugs JT - Journal of psychoactive drugs JID - 8113536 RN - 0 (Hallucinogens) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - Adult MH - Aged MH - Autistic Disorder/*drug therapy/psychology MH - Female MH - Hallucinogens/*administration & dosage/adverse effects/pharmacology MH - Humans MH - Interviews as Topic MH - Male MH - Middle Aged MH - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/adverse effects/pharmacology MH - Phobia, Social/psychology MH - Surveys and Questionnaires MH - Young Adult OTO - NOTNLM OT - Asperger's OT - MDMA OT - autism OT - social anxiety EDAT- 2019/03/27 06:00 MHDA- 2020/05/23 06:00 CRDT- 2019/03/27 06:00 PHST- 2019/03/27 06:00 [pubmed] PHST- 2020/05/23 06:00 [medline] PHST- 2019/03/27 06:00 [entrez] AID - 10.1080/02791072.2019.1587116 [doi] PST - ppublish SO - J Psychoactive Drugs. 2019 Apr-Jun;51(2):146-154. doi: 10.1080/02791072.2019.1587116. Epub 2019 Mar 25.