PMID- 30910198
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 53
DP  - 2019 May
TI  - The analysis of Cu, Mn and Zn content in prescription food for special medical 
      purposes and modified milk products for newborns and infants available in Polish 
      pharmacies from toxicological and nutritional point of view.
PG  - 144-149
LID - S0946-672X(19)30025-2 [pii]
LID - 10.1016/j.jtemb.2019.03.001 [doi]
AB  - BACKGROUND: Prescription food for special medical purposes (FSMPs) and modified 
      milk products (MMPs), available in pharmacies, are important for newborns and 
      infants that are not breastfed. In the scientific literature there is a lack of 
      comprehensive studies and corresponding safety assessment of the essential trace 
      elements in these products. OBJECTIVE: The aim of this article was determination 
      of Cu, Mn and Zn levels in the most frequently available prescription FSMPs 
      (n = 6) and MMPs (n = 6) available in Polish pharmacies. METHODS: Flame 
      absorption spectrometry (FAAS) following microwave induced digestion 
      (concentrated nitric acid) was applied to determine the levels of the elements in 
      the products. RESULTS: Our studies are based on a triple approach (1) the "raw 
      results" of Cu, Mn and Zn levels (products in powdered form), (2) single intake - 
      the level of each essential trace element consumed in one portion, (3) the daily 
      intake depending on age and weight including comparison with Adequate Intake 
      established by European Food Safety Authority. CONCLUSION: The results show the 
      occurrence of differences between the manufacturer's declared composition and the 
      finished product for consumption. The prescription FSMPs in comparison to MMPs 
      available in Polish pharmacies contain similar levels of Cu, Mn and Zn. Our 
      results show additionally that all of the products do not represent a health 
      hazard to the newborns and infants. This is a pioneer study in terms of the 
      safety assessment, and quality of prescription FSMPs and MMPs available in Polish 
      pharmacies from toxicological and nutritional point of view.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Jurowski, Kamil
AU  - Jurowski K
AD  - Independent Researcher, Poland; Faculty of Health Promotion, Krakow Higher School 
      of Health Promotion, Krowoderska 73, 31-158 Krakow, Poland. Electronic address: 
      kamil.jurowski@gmail.com.
FAU - Krosniak, Miroslaw
AU  - Krosniak M
AD  - Department of Food Chemistry and Nutrition, Medical College, Jagiellonian 
      University, Medyczna 9, 30-688 Krakow, Poland.
FAU - Folta, Maria
AU  - Folta M
AD  - Department of Food Chemistry and Nutrition, Medical College, Jagiellonian 
      University, Medyczna 9, 30-688 Krakow, Poland.
FAU - Tatar, Barbara
AU  - Tatar B
AD  - Department of Food Chemistry and Nutrition, Medical College, Jagiellonian 
      University, Medyczna 9, 30-688 Krakow, Poland.
FAU - Cole, Michael
AU  - Cole M
AD  - Faculty of Science and Technology, Anglia Ruskin University, East Road, 
      Cambridge, United Kingdom.
FAU - Piekoszewski, Wojciech
AU  - Piekoszewski W
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University 
      in Krakow, Gronostajowa 2, 30-387 Krakow, Poland; School of Biomedicine, Far 
      Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.
LA  - eng
PT  - Journal Article
DEP - 20190307
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Prescription Drugs)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
MH  - Copper/*analysis
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Manganese/*analysis
MH  - Microwaves
MH  - Milk, Human/*chemistry
MH  - *Pharmacies
MH  - Poland
MH  - Prescription Drugs/*chemistry
MH  - Zinc/*analysis
OTO - NOTNLM
OT  - Copper
OT  - Manganase
OT  - Modified milk products
OT  - Prescription food for special medical purposes
OT  - Toxicological analysis
OT  - Zinc
EDAT- 2019/03/27 06:00
MHDA- 2019/08/09 06:00
CRDT- 2019/03/27 06:00
PHST- 2019/01/11 00:00 [received]
PHST- 2019/02/12 00:00 [revised]
PHST- 2019/03/06 00:00 [accepted]
PHST- 2019/03/27 06:00 [entrez]
PHST- 2019/03/27 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
AID - S0946-672X(19)30025-2 [pii]
AID - 10.1016/j.jtemb.2019.03.001 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2019 May;53:144-149. doi: 10.1016/j.jtemb.2019.03.001. 
      Epub 2019 Mar 7.