PMID- 3091191
OWN - NLM
STAT- MEDLINE
DCOM- 19861008
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 379
IP  - 1
DP  - 1986 Jul 30
TI  - Magnetic field inhibition of morphine-induced analgesia and behavioral activity 
      in mice: evidence for involvement of calcium ions.
PG  - 30-8
AB  - An exposure for 60 min to a 0.5 Hz rotating magnetic field (1.5-90 G) 
      significantly reduced the day-time analgesic (in CF-1 mice) and locomotory (in 
      C-57BL mice) effects of morphine (10 mg/kg). Intracerebroventricular (i.c.v.) 
      injections of a calcium chelator, EGTA, blocked these effects, while 
      administration of the calcium ionophore, A23187, potentiated the inhibitory 
      actions. In a parallel fashion, i.c.v. administration of Ca2+ reduced, in a 
      dose-related manner, the analgesic and locomotory effects of morphine in control 
      CF-1 and C57 mice. These latter inhibitory effects could also be blocked by EGTA 
      and augmented by A23187, indicating that opiate effects on activity and 
      nociception are both sensitive to antagonism by calcium. Taken together these 
      results suggest that exposure to magnetic stimuli may alter morphine-induced 
      responses in mice, in a manner compatible and consistent with effects on Ca2+ and 
      possibly other divalent ions.
FAU - Kavaliers, M
AU  - Kavaliers M
FAU - Ossenkopp, K P
AU  - Ossenkopp KP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 37H9VM9WZL (Calcimycin)
RN  - 526U7A2651 (Egtazic Acid)
RN  - 76I7G6D29C (Morphine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Analgesia
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Calcimycin/pharmacology
MH  - Calcium/*pharmacology
MH  - Egtazic Acid/pharmacology
MH  - Hot Temperature
MH  - *Magnetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Morphine/*pharmacology
MH  - *Neural Inhibition
MH  - Reaction Time/drug effects
EDAT- 1986/07/30 00:00
MHDA- 1986/07/30 00:01
CRDT- 1986/07/30 00:00
PHST- 1986/07/30 00:00 [pubmed]
PHST- 1986/07/30 00:01 [medline]
PHST- 1986/07/30 00:00 [entrez]
AID - 0006-8993(86)90252-0 [pii]
AID - 10.1016/0006-8993(86)90252-0 [doi]
PST - ppublish
SO  - Brain Res. 1986 Jul 30;379(1):30-8. doi: 10.1016/0006-8993(86)90252-0.