PMID- 30914115
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20190820
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 35
IP  - 1
DP  - 2019 Jan
TI  - [CD226 knockout aggravates radiation-induced liver injury in mice].
PG  - 46-51
AB  - Objective To investigate the effect of CD226 knockout (KO) on radiation-induced 
      liver injury in mice. Methods Wild-type (WT) and CD226KO mice were randomly 
      divided into naive group and irradiated group. The mice in the irradiated group 
      were exposed to an 8 Gy of (60)Co gamma-radiation. The survival rate was observed and 
      body mass loss was measured. The pathological changes in the liver and colon were 
      examined by HE staining, and the mRNA levels of inflammatory factors, including 
      inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), IL-6, IL-12p40, 
      tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) 
      were detected by real-time quantitative PCR. Results Compared with the irradiated 
      WT mice, the irradiated CD226KO mice had increased body mass loss and decreased 
      survival rate. In the irradiated CD226KO mice, the liver injury was more serious, 
      the liver index (liver mass/body mass) was reduced, and the expressive levels of 
      iNOS, IL-1beta, IL-6, IL-12p40, TNF-alpha and MCP-1 were enhanced; whereas, the colitis 
      was less serious, and the expressive levels of inflammatory factors were 
      down-regulated. Conclusion The deficiency of CD226 can decrease the survival rate 
      of irradiated mice, which is associated with the aggravated liver injury.
FAU - Hu, Wei
AU  - Hu W
AD  - Department of Immunology, Transplant Immunology Laboratory, School of Basic 
      Medical Sciences, Air Force Military Medical University, Xi'an 710032, China.
FAU - Zhang, Dongliang
AU  - Zhang D
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Zhou, Gengyao
AU  - Zhou G
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Zhang, Jinxue
AU  - Zhang J
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Yi, Xin
AU  - Yi X
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Xie, Jiangang
AU  - Xie J
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Transplant Immunology Laboratory, School of Basic Medical Sciences, Air Force 
      Military Medical University, Xi'an 710032, China.
FAU - Yang, Kun
AU  - Yang K
AD  - Department of Immunology, School of Basic Medical Sciences, Air Force Military 
      Medical University, Xi'an 710032, China.
FAU - Zhuang, Ran
AU  - Zhuang R
AD  - Department of Immunology, Transplant Immunology Laboratory, School of Basic 
      Medical Sciences, Air Force Military Medical University, Xi'an 710032, China. 
      *Corresponding author, E-mail: fmmuzhr@fmmu.edu.cn.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD226 antigen)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
MH  - Animals
MH  - Antigens, Differentiation, T-Lymphocyte
MH  - Interleukin-1beta
MH  - *Liver
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Tumor Necrosis Factor-alpha
EDAT- 2019/03/28 06:00
MHDA- 2019/08/21 06:00
CRDT- 2019/03/28 06:00
PHST- 2019/03/28 06:00 [entrez]
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Jan;35(1):46-51.