PMID- 30914242
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20190718
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 194
DP  - 2019 Jun
TI  - Gastrointestinal effects of ivermectin treatment in rats infected with 
      Strongyloides venezuelensis.
PG  - 69-77
LID - S0001-706X(18)31143-4 [pii]
LID - 10.1016/j.actatropica.2019.03.024 [doi]
AB  - We aimed to evaluate the effects of ivermectin treatment on gastrointestinal 
      morphology and function after Strongyloides venezuelensis infection. Male rats 
      composed Control (C), Parasitized (Sv), Ivermectin (IVM) and Parasitized and 
      treated with Ivermectin (Sv/IVM) groups. IVM and Sv/IVM groups were subdivided 
      according to IVM: single dose of 200 mug/kg (IVM1 and Sv/IVM1) or three repeated 
      doses of 200 mug/kg at 24 h intervals (IVM3 and Sv/IVM3). First dose of IVM was 
      administered after peak of infection. Eggs per gram (EPG), mean gastric emptying 
      time (MGET), mean cecum arrival time (MCAT) and mean small intestinal transit 
      time (MSITT) were evaluated. Measurements were performed before drug and at peak 
      of infection, first day post peak of infection and 30 days post infection. Same 
      time intervals were simulated for uninfected animals. Number of recovered worms 
      and intestinal morphometry were also rated. Data were analyzed by ANOVA and 
      correlated by Dunnett and Pearson (p < 0.05). Sv/IVM1 and Sv/IVM3 showed 
      reduction of EPG and worms, although only group SV/IVM3 eradicate them. Hastened 
      gastric emptying and slowed intestinal transit provoked by S. venezuelensis 
      infection can be reverted by a single administration of IVM after peak of 
      infection, even without total parasite elimination. Although three consecutive 
      doses of IVM were more efficient to eradicate the parasite, drug administration 
      impaired gastrointestinal function and morphology. IVM alone affected 
      gastrointestinal parameters in uninfected animals for prolonged periods, 
      especially in high doses. In control, there were strong negative correlations 
      between MSITT and muscle layers. Strongyloides venezuelensis infection abolishes 
      such correlations. Longitudinal muscle was thinner in IVM3 and Sv/IVM3 groups and 
      circular thicker in Sv group. Revisiting the action of traditional drugs broadens 
      knowledge in the parasite-host interface and may result in the development of 
      more accurate therapeutic strategies.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Mendonca, Jalvita C
AU  - Mendonca JC
AD  - Federal University of Mato Grosso - UFMT, Barra do Garcas, MT, Brazil.
FAU - Gama, Loyane A
AU  - Gama LA
AD  - Sao Paulo State University - UNESP, Botucatu, SP, Brazil.
FAU - Hauschildt, Andrieli T
AU  - Hauschildt AT
AD  - Federal University of Ceara - UFC, Fortaleza, Brazil.
FAU - Cora, Luciana A
AU  - Cora LA
AD  - Alagoas State University of Health Sciences - UNCISAL, Maceio, AL, Brazil.
FAU - Americo, Madileine F
AU  - Americo MF
AD  - Federal University of Mato Grosso - UFMT, Barra do Garcas, MT, Brazil. Electronic 
      address: madileine@pq.cnpq.br.
LA  - eng
PT  - Journal Article
DEP - 20190323
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Antiparasitic Agents)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Animals
MH  - Antiparasitic Agents/*pharmacology
MH  - Disease Models, Animal
MH  - Feces/parasitology
MH  - Gastrointestinal Transit/physiology
MH  - Intestine, Small/*drug effects/parasitology
MH  - Ivermectin/*pharmacology
MH  - Male
MH  - Parasite Egg Count
MH  - Rats
MH  - Rats, Wistar/parasitology
MH  - Strongyloides/*drug effects/physiology
MH  - Strongyloidiasis/*drug therapy/parasitology/*physiopathology
OTO - NOTNLM
OT  - Gastrointestinal transit
OT  - Ivermectin
OT  - Strongyloides venezuelensis
OT  - Strongyloidiasis
EDAT- 2019/03/28 06:00
MHDA- 2019/07/19 06:00
CRDT- 2019/03/28 06:00
PHST- 2018/09/11 00:00 [received]
PHST- 2019/03/14 00:00 [revised]
PHST- 2019/03/22 00:00 [accepted]
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2019/03/28 06:00 [entrez]
AID - S0001-706X(18)31143-4 [pii]
AID - 10.1016/j.actatropica.2019.03.024 [doi]
PST - ppublish
SO  - Acta Trop. 2019 Jun;194:69-77. doi: 10.1016/j.actatropica.2019.03.024. Epub 2019 
      Mar 23.