PMID- 30914517
OWN - NLM
STAT- MEDLINE
DCOM- 20190823
LR  - 20190823
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 46
IP  - 2
DP  - 2019 Feb
TI  - [Carcinogenesis and Gut Microbiota].
PG  - 199-204
AB  - Recent developments in techniques of metabologenomics have given a better 
      understanding the association of gut microbiota with various diseases. Gut 
      microbiota has a strong impact on host immunostasis and homeostasis of gut 
      function for maintaining the health condition. Dysbiosis leads to an increase in 
      bacterial populations that stimulate tumorigenesis, and contributes to epithelial 
      carcinogenesis and tumor progression by altering metabolic properties(such as 
      bile acid and butyric acid)and inflammatory process. Inflammation aid the 
      bacterial translocation into the neoplastic tissue, which in turn promotes 
      production of inflammatory cytokines subsequently leading to tumor growth. The 
      colonic microbiota such as enterotoxigenic Bacteroides fragilis(ETBF)may also 
      promote colorectal cancer by stimulating exaggerated immune responses via Th17 
      cells. Dysbiosis caused by a deficiency of the NLRP6 inflammasome promotes cancer 
      development via interleukin-6(IL- 6)-induced epithelial proliferation. Emerging 
      data suggest that certain groups of bacteria might promote whereas others might 
      protect against colon cancer. Indeed, Fusobacteriumnucleatum (F. nucleatum)seems 
      to play a central role in the tumor microenvironment as its abundance correlates 
      with cancer progression as well as the dysbiotic tumor microbiota composition 
      including Bacteroides and Prevotella species. Moreover, gut microbiota not only 
      plays a key role in carcinogenesis but also influences the efficacy and toxicity 
      of cancer immunotherapy, especially immune checkpoint inhibitors by targeting the 
      programmed death receptor 1(PD-1)and the cytotoxic T lymphocyte antigen 
      4(CTLA-4).
FAU - Shiotani, Akiko
AU  - Shiotani A
AD  - Division of Gastroenterology, Dept. of Internal Medicine, Kawasaki Medical 
      School.
FAU - Fukushima, Shinya
AU  - Fukushima S
FAU - Matsumoto, Hiroshi
AU  - Matsumoto H
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
MH  - *Carcinogenesis
MH  - Cell Transformation, Neoplastic
MH  - *Colorectal Neoplasms
MH  - Dysbiosis
MH  - *Gastrointestinal Microbiome
MH  - Humans
EDAT- 2019/03/28 06:00
MHDA- 2019/08/24 06:00
CRDT- 2019/03/28 06:00
PHST- 2019/03/28 06:00 [entrez]
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2019/08/24 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2019 Feb;46(2):199-204.