PMID- 30915450
OWN - NLM
STAT- MEDLINE
DCOM- 20200128
LR  - 20200128
IS  - 1943-7730 (Electronic)
IS  - 0007-5027 (Linking)
VI  - 50
IP  - 4
DP  - 2019 Oct 10
TI  - Post-Transfusion Purpura Mimicking Idiopathic Thrombocytopenic Purpura: A Case 
      Report.
PG  - 396-400
LID - 10.1093/labmed/lmz004 [doi]
AB  - The main clinical distinction between post-transfusion purpura (PTP) and 
      idiopathic thrombocytopenic purpura (ITP) is the sudden development of severe 
      thrombocytopenia in the days after transfusion. Herein, we report the case of a 
      53-year-old Caucasian woman who developed multiple myeloma (MM) after peripheral 
      blood-stem-cell transplant (PBSCT), along with severe thrombocytopenia (with a 
      nadir of 1 x 109/L); she also experienced severe adverse events after each 
      platelet transfusion, including the first one. These reactions were absent with 
      any other transfused blood products. The results of an human leukocyte antigen 
      (HLA) class-1 panel reactive antibody assay were 0%, and the results of a 
      platelet-antibody screening assay were positive for HLA class-1 antibodies and 
      glycoprotein (Gp)IIb/IIIa antibodies. Her platelet count reached 42 x 109 per L 
      on day 50, after rituximab on day 22 and daratumumab on day 29. Her clinical 
      scenario was most consistent with the course of PTP.
CI  - (c) American Society for Clinical Pathology 2019. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Milito, Chelsea
AU  - Milito C
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Masel, Debra
AU  - Masel D
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Henrichs, Kelly
AU  - Henrichs K
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Schmidt, Amy E
AU  - Schmidt AE
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Kirkley, Scott
AU  - Kirkley S
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Aljitawi, Omar
AU  - Aljitawi O
AD  - Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical 
      Center, Rochester, NY.
FAU - Becker, Michael
AU  - Becker M
AD  - Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical 
      Center, Rochester, NY.
FAU - Blumberg, Neil
AU  - Blumberg N
AD  - Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, 
      Rochester, NY.
FAU - Refaai, Majed A
AU  - Refaai MA
AD  - Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical 
      Center, Rochester, NY.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Lab Med
JT  - Laboratory medicine
JID - 0250641
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies/blood
MH  - Diagnosis, Differential
MH  - Drug-Related Side Effects and Adverse Reactions/*pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Platelet Count
MH  - Purpura, Thrombocytopenic, Idiopathic/*pathology
MH  - Stem Cell Transplantation/*adverse effects
MH  - Transfusion Reaction/*diagnosis/*pathology
OTO - NOTNLM
OT  - platelet
OT  - post-transfusion purpura
OT  - thrombocytopenia
OT  - thrombocytopenic purpura
OT  - transfusion
OT  - transfusion complications
EDAT- 2019/03/28 06:00
MHDA- 2020/01/29 06:00
CRDT- 2019/03/28 06:00
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2020/01/29 06:00 [medline]
PHST- 2019/03/28 06:00 [entrez]
AID - 5420471 [pii]
AID - 10.1093/labmed/lmz004 [doi]
PST - ppublish
SO  - Lab Med. 2019 Oct 10;50(4):396-400. doi: 10.1093/labmed/lmz004.