PMID- 30916121
OWN - NLM
STAT- MEDLINE
DCOM- 20190612
LR  - 20200309
IS  - 1678-9741 (Electronic)
IS  - 0102-7638 (Print)
IS  - 0102-7638 (Linking)
VI  - 34
IP  - 2
DP  - 2019 Mar-Apr
TI  - Benefits of Fasting Abbreviation with Carbohydrates and Omega-3 Infusion During 
      CABG: a Double-Blind Controlled Randomized Trial.
PG  - 125-135
LID - S0102-76382019000200004 [pii]
LID - 10.21470/1678-9741-2018-0336 [doi]
AB  - OBJECTIVE: To assess postoperative clinical data considering the association of 
      preoperative fasting with carbohydrate (CHO) loading and intraoperative infusion 
      of omega-3 polyunsaturated fatty acids (omega-3 PUFA). METHODS: 57 patients 
      undergoing coronary artery bypass grafting (CABG) were randomly assigned to 
      receive 12.5% maltodextrin (200 mL, 2 h before anesthesia), (CHO, n=14); water 
      (200 mL, 2 h before anesthesia), (control, n=14); 12.5% maltodextrin (200 mL, 2 h 
      before anesthesia) plus intraoperative infusion of omega-3 PUFA (0.2 g/kg), (CHO+W3, 
      n=15); or water (200 mL, 2 h before anesthesia) plus intraoperative infusion of 
      omega-3 PUFA (0.2 g/kg), (W3, n=14). The need for vasoactive drugs was analyzed, in 
      addition to postoperative inflammation and metabolic control. RESULTS: There were 
      two deaths (3.5%). Patients in CHO groups presented a lower incidence of hospital 
      infection (RR=0.29, 95% CI 0.09-0.94; P=0.023), needed fewer vasoactive drugs 
      during surgery and ICU stay (P<0.05); and had better blood glucose levels in the 
      first six hours of recovery (P=0.015), requiring less exogenous insulin 
      (P=0.018). Incidence of postoperative atrial fibrillation (POAF) varied 
      significantly among groups (P=0.009). Subjects who receive omega-3 PUFA groups had 
      fewer occurrences of POAF (RR=4.83, 95% CI 1.56-15.02; P=0.001). Patients in the 
      W3 group had lower ultrasensitive-CRP levels at 36 h postoperatively (P=0.008). 
      Interleukin-10 levels varied among groups (P=0.013), with the highest levels 
      observed in the postoperative of patients who received intraoperative infusion of 
      omega-3 PUFA (P=0.049). CONCLUSION: Fasting abbreviation with carbohydrate loading 
      and intraoperative infusion of omega-3 PUFA is safe and supports faster postoperative 
      recovery in patients undergoing on-pump CABG.
FAU - Feguri, Gibran Roder
AU  - Feguri GR
AUID- ORCID: 0000-0002-1132-9667
AD  - Department of Cardiology and Cardiovascular Surgery, Hospital Geral 
      Universitario, Universidade de Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Lima, Paulo Ruiz Lucio de
AU  - Lima PRL
AD  - Department of Cardiology and Cardiovascular Surgery, Hospital Geral 
      Universitario, Universidade de Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Franco, Anna Carolina
AU  - Franco AC
AD  - Department of Cardiovascular Surgery, Hospital Geral Universitario, Universidade 
      de Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Cruz, Felipe Ramos Honorato De La
AU  - Cruz FRH
AD  - Department of Cardiovascular Surgery, Hospital Geral Universitario, Universidade 
      de Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Borges, Danilo Cerqueira
AU  - Borges DC
AD  - Department of Cardiology and Cardiovascular Surgery, Hospital Geral 
      Universitario, Universidade de Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Toledo, Laura Ramos
AU  - Toledo LR
AD  - Department of Physical Therapy, Hospital Geral Universitario, Universidade de 
      Cuiaba (HGU-UNIC), Cuiaba, MT, Brazil.
FAU - Segri, Neuber Jose
AU  - Segri NJ
AD  - Department of Statistics, Universidade Federal do Mato Grosso (UFMT), Cuiaba, MT, 
      Brazil.
FAU - Aguilar-Nascimento, Jose Eduardo de
AU  - Aguilar-Nascimento JE
AD  - Universidade Federal do Mato Grosso (UFMT), Cuiaba, MT, Brazil.
AD  - Universidade de Varzea Grande (UNIVAG), Varzea Grande, MT, Brazil.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Brazil
TA  - Braz J Cardiovasc Surg
JT  - Brazilian journal of cardiovascular surgery
JID - 101677045
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Blood Glucose/analysis
MH  - Coronary Artery Bypass/*methods/rehabilitation
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Double-Blind Method
MH  - *Fasting
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Perioperative Period
MH  - Postoperative Complications/prevention & control
MH  - Prospective Studies
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC6436776
COIS- No conflict of interest.
EDAT- 2019/03/28 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/03/01
CRDT- 2019/03/28 06:00
PHST- 2018/10/22 00:00 [received]
PHST- 2018/10/31 00:00 [accepted]
PHST- 2019/03/28 06:00 [entrez]
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - S0102-76382019000200004 [pii]
AID - 10.21470/1678-9741-2018-0336 [doi]
PST - ppublish
SO  - Braz J Cardiovasc Surg. 2019 Mar-Apr;34(2):125-135. doi: 
      10.21470/1678-9741-2018-0336.