PMID- 30916218
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20200225
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 52
IP  - 3
DP  - 2019 Mar 25
TI  - Association between tumor necrosis factor polymorphisms and rheumatoid arthritis 
      as well as systemic lupus erythematosus: a meta-analysis.
PG  - e7927
LID - S0100-879X2019000300607 [pii]
LID - 10.1590/1414-431X20187927 [doi]
LID - e7927
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays an important role in autoimmune 
      diseases. Previous studies have investigated the association of TNF-alpha-238G/A 
      (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) 
      and systemic lupus erythematosus (SLE). However, no agreed conclusion had been 
      made. Therefore, this meta-analysis was conducted to assess the associations of 
      TNF-alpha-238G/A and -308G/A polymorphisms with RA and SLE risk. A systematic search 
      was conducted in commonly used databases. Meta-analysis was performed by 
      STATA12.0. A total of 43 studies were included. In the overall population, the 
      TNF-alpha-238A allele was observed to be a protective factor for RA (A vs G: OR=0.75, 
      95%CI=0.57-0.99, P=0.040) and the TNF-alpha-308A allele was found to be a risk factor 
      for SLE (A vs G: OR=1.78, 95%CI=1.45-2.19, P<0.001). However, no evidence of 
      association was found between TNF-alpha-238 G/A polymorphism and SLE nor between 
      -308G/A and RA. In the subgroup analysis, TNF-alpha-308A allele played a pathogenic 
      role for RA in Latin Americans (A vs G: OR=1.46, 95%CI=1.15-1.84, P=0.002) and 
      for SLE in Latin Americans (A vs G: OR=2.12, 95%CI=1.32-3.41, P=0.002) and 
      Europeans (A vs G: OR=2.03, 95%CI=1.56-2.63, P<0.001), while it played a 
      protective role for RA in Asians (A vs G: OR=0.54, 95%CI=0.32-0.90, P=0.017). No 
      significant association was found between TNF-alpha-308G/A and SLE susceptibility in 
      Africans and Asians. This meta-analysis demonstrated that TNF-alpha-238A was 
      associated with decreased risk of RA rather than SLE, while -308G/A polymorphism 
      was associated with SLE rather than RA. Stratification analysis indicated that 
      different ethnicities would have different risk alleles.
FAU - Chen, Lin
AU  - Chen L
AUID- ORCID: 0000-0002-9547-0261
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children, 
      Ministry of Education, Department of Obstetrics and Gynecology, West China Second 
      University Hospital, Sichuan University, Chengdu, China.
FAU - Huang, Zhuochun
AU  - Huang Z
AUID- ORCID: 0000-0002-0415-1426
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Liao, Yun
AU  - Liao Y
AUID- ORCID: 0000-0001-6603-7437
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Yang, Bin
AU  - Yang B
AUID- ORCID: 0000-0003-3679-6664
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Zhang, Junlong
AU  - Zhang J
AUID- ORCID: 0000-0002-5196-2707
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190325
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC6437938
EDAT- 2019/03/28 06:00
MHDA- 2019/05/08 06:00
PMCR- 2019/03/25
CRDT- 2019/03/28 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/12/10 00:00 [accepted]
PHST- 2019/03/28 06:00 [entrez]
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2019/03/25 00:00 [pmc-release]
AID - S0100-879X2019000300607 [pii]
AID - 10.1590/1414-431X20187927 [doi]
PST - epublish
SO  - Braz J Med Biol Res. 2019 Mar 25;52(3):e7927. doi: 10.1590/1414-431X20187927.