PMID- 30917353
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20220113
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 64
IP  - 9
DP  - 2019 Apr 23
TI  - Assessment of 3D motion modeling performance for dose accumulation mapping on the 
      MR-linac by simultaneous multislice MRI.
PG  - 095004
LID - 10.1088/1361-6560/ab13e3 [doi]
AB  - Hybrid MR-linac systems enable intrafraction motion monitoring during radiation 
      therapy. Since time-resolved 3D MRI is still challenging, various motion models 
      have been developed that rely on time-resolved 2D imaging. Continuous validation 
      of these models is important for accurate dose accumulation mapping. In this 
      study we used 2D simultaneous multislice (SMS) imaging to improve the PCA-based 
      motion modeling method developed previously (Stemkens et al 2016 Phys. Med. Biol. 
      61 5335-55). From the additional simultaneously acquired slices, several 
      independent motion models could be generated, which allowed for an assessment of 
      the sensitivity of the motion model to the location of the time-resolved 2D 
      slices. Additionally, the best model could be chosen at every time-point, 
      increasing the method's robustness. Imaging experiments were performed in six 
      healthy volunteers using three simultaneous slices, which generated three 
      independent models per volunteer. For each model the motion traces of the liver 
      tip and both kidneys were estimated. We found that the location of the 2D slices 
      influenced the model's error in five volunteers significantly with a 
      p -value  <0.05, and that selecting the best model at every time-point can 
      improve the method. This allows for more accurate and robust motion 
      characterization in MR-guided radiotherapy.
FAU - Borman, P T S
AU  - Borman PTS
AD  - Department of Radiotherapy, University Medical Center Utrecht. Heidelberglaan 
      100, 3584 CX, Utrecht, The Netherlands.
AD  - Imaging Division, University Medical Center Utrecht. Heidelberglaan 100, 3584 CX, 
      Utrecht, The Netherlands.
AD  - Author to whom any correspondence should be addressed.
FAU - Bos, C
AU  - Bos C
AD  - Imaging Division, University Medical Center Utrecht. Heidelberglaan 100, 3584 CX, 
      Utrecht, The Netherlands.
FAU - Stemkens, B
AU  - Stemkens B
AUID- ORCID: 0000-0003-0488-8070
AD  - Department of Radiotherapy, University Medical Center Utrecht. Heidelberglaan 
      100, 3584 CX, Utrecht, The Netherlands.
AD  - MR Code B.V. Schimminck 18, 5301 KR, Zaltbommel, The Netherlands.
FAU - Moonen, C T W
AU  - Moonen CTW
AD  - Imaging Division, University Medical Center Utrecht. Heidelberglaan 100, 3584 CX, 
      Utrecht, The Netherlands.
FAU - Raaymakers, B W
AU  - Raaymakers BW
AD  - Department of Radiotherapy, University Medical Center Utrecht. Heidelberglaan 
      100, 3584 CX, Utrecht, The Netherlands.
FAU - Tijssen, R H N
AU  - Tijssen RHN
AD  - Department of Radiotherapy, University Medical Center Utrecht. Heidelberglaan 
      100, 3584 CX, Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190423
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - Dose Fractionation, Radiation
MH  - Healthy Volunteers
MH  - Humans
MH  - Liver/diagnostic imaging/radiation effects
MH  - Magnetic Resonance Imaging/*instrumentation
MH  - *Models, Biological
MH  - *Movement
MH  - *Particle Accelerators
MH  - Phantoms, Imaging
MH  - *Radiation Dosage
MH  - Radiotherapy, Image-Guided/*methods
EDAT- 2019/03/28 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/03/28 06:00
PHST- 2019/03/28 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/03/28 06:00 [entrez]
AID - 10.1088/1361-6560/ab13e3 [doi]
PST - epublish
SO  - Phys Med Biol. 2019 Apr 23;64(9):095004. doi: 10.1088/1361-6560/ab13e3.