PMID- 30918817
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 12
IP  - 3
DP  - 2019
TI  - Discriminating performance of macular ganglion cell-inner plexiform layer 
      thicknesses at different stages of glaucoma.
PG  - 464-471
LID - 10.18240/ijo.2019.03.18 [doi]
AB  - AIM: To determine the discriminating performance of the macular ganglion 
      cell-inner plexiform layer (GC-IPL) parameters between all the consecutive stages 
      of glaucoma (from healthy to moderate-to-severe glaucoma), and to compare it with 
      the discriminating performances of the peripapillary retinal nerve fiber layer 
      (RNFL) parameters and optic nerve head (ONH) parameters. METHODS: Totally 147 
      eyes (40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 
      moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence 
      tomography (OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic 
      performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining 
      the area under the curve (AUC) of the receiver operating characteristics. 
      RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from 
      subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma 
      patients (P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL 
      parameters discriminated early glaucoma patients from glaucoma suspects, whereas 
      no RNFL or ONH parameter could discriminate between the two. The best parameters 
      to discriminate glaucoma suspects from subjects with healthy eyes were 
      superonasal GC-IPL, superior RNFL and average c/d ratio (AUC=0.746, 0.810 and 
      0.746, respectively). Discriminating performances of all the parameters for early 
      glaucoma vs glaucoma suspect comparison were lower than that of the other 
      consecutive group comparisons, with the best GC-IPL parameters being minimum and 
      inferotemporal (AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, 
      average RNFL, and rim area (AUC=0.900, 0.858, 0.768, respectively) were the best 
      parameters for discriminating moderate-to-severe glaucoma patients from early 
      glaucoma patients. CONCLUSION: GC-IPL parameters can discriminate glaucoma 
      suspect patients from subjects with healthy eyes, and also all the consecutive 
      stages of glaucoma from each other (from glaucoma suspect to moderate-to-severe 
      glaucoma). Further, the discriminating performance of GC-IPL thicknesses is 
      comparable to that.
FAU - Ustaoglu, Melih
AU  - Ustaoglu M
AD  - Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA 19107, USA.
AD  - Ophthalmology Clinic, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul 34371, Turkey.
FAU - Solmaz, Nilgun
AU  - Solmaz N
AD  - Ophthalmology Clinic, Haseki Training and Research Hospital, Istanbul 34096, 
      Turkey.
FAU - Onder, Feyza
AU  - Onder F
AD  - Ophthalmology Clinic, Haseki Training and Research Hospital, Istanbul 34096, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190318
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC6423388
OTO - NOTNLM
OT  - cirrus HD-OCT
OT  - ganglion cell-inner plexiform layer
OT  - glaucoma suspect
OT  - optic nerve head
OT  - retinal nerve fiber layer
EDAT- 2019/03/29 06:00
MHDA- 2019/03/29 06:01
PMCR- 2019/03/18
CRDT- 2019/03/29 06:00
PHST- 2018/04/26 00:00 [received]
PHST- 2018/12/24 00:00 [accepted]
PHST- 2019/03/29 06:00 [entrez]
PHST- 2019/03/29 06:00 [pubmed]
PHST- 2019/03/29 06:01 [medline]
PHST- 2019/03/18 00:00 [pmc-release]
AID - ijo-12-03-464 [pii]
AID - 10.18240/ijo.2019.03.18 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2019 Mar 18;12(3):464-471. doi: 10.18240/ijo.2019.03.18. 
      eCollection 2019.