PMID- 30918853
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Dec
TI  - Effect of type 2 diabetes mellitus on treatment outcomes of patients with 
      postmenopausal osteoporosis: a retrospective study.
PG  - 181-187
LID - 10.1007/s40200-018-0359-1 [doi]
AB  - OBJECTIVES: The aim of this study is to investigate the effect of type 2 diabetes 
      mellitus (T2DM) on the treatment outcomes of patients with postmenopausal 
      osteoporosis (PMOP). MATERIAL AND METHOD: Thirty-five patients who had been 
      diagnosed as PMOP by lumbar and/or femoral neck bone mineral density screening 
      (BMD) and who had comorbid T2DM were included in the study. Thirty-five patients 
      who had been diagnosed as PMOP but who had no comorbidity including DM 
      constituted the control group. Demographic features, biochemical parameters, 
      femoral and lumbar T scores were all recorded. All patients were treated with 
      bisphosphonate, calcium and vitamin D and the same parameters were evaluated at 
      the end of the first and fifth year. RESULTS: Lumbar T scores and serum 
      osteocalcin levels before treatment were significantly lower in the DM + PMOP 
      group (p < 0,05). At the end of 5 years, despite the lumbar T score having 
      increased, the femoral T score was found to be significantly lower in the 
      DM + PMOP group. In the PMOP group, there was significant improvement in the T 
      scores and serum osteocalcin levels following a 5-year treatment period 
      (p < 0,05). CONCLUSIONS: T2DM has unfavorable effects on treatment prognosis in 
      patients with PMOP. Different risk factors of PMOP which differ in the general 
      population maybe more important when evaluating fracture risk in patients wtih 
      T2DM.
FAU - Yilmaz, Volkan
AU  - Yilmaz V
AD  - Physical Medicine and Rehabilitation Clinic, Ankara Diskapi Yildirim Beyazit 
      Training and Research Hospital, Irfan Bastug Street, Altindag, Ankara, Turkey. 
      ISNI: 0000 0004 0419 0366. GRID: grid.413698.1
FAU - Umay, Ebru
AU  - Umay E
AD  - Physical Medicine and Rehabilitation Clinic, Ankara Diskapi Yildirim Beyazit 
      Training and Research Hospital, Irfan Bastug Street, Altindag, Ankara, Turkey. 
      ISNI: 0000 0004 0419 0366. GRID: grid.413698.1
FAU - Gundogdu, Ibrahim
AU  - Gundogdu I
AD  - Physical Medicine and Rehabilitation Clinic, Ankara Diskapi Yildirim Beyazit 
      Training and Research Hospital, Irfan Bastug Street, Altindag, Ankara, Turkey. 
      ISNI: 0000 0004 0419 0366. GRID: grid.413698.1
FAU - Tezel, Nihal
AU  - Tezel N
AD  - Physical Medicine and Rehabilitation Clinic, Ankara Diskapi Yildirim Beyazit 
      Training and Research Hospital, Irfan Bastug Street, Altindag, Ankara, Turkey. 
      ISNI: 0000 0004 0419 0366. GRID: grid.413698.1
LA  - eng
PT  - Journal Article
DEP - 20181026
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC6405402
OTO - NOTNLM
OT  - Osteoporosis
OT  - Postmenopausal
OT  - Treatment
OT  - Type 2 diabetes mellitus
COIS- There is no conflict of interest among the authors. There is no financial and/or 
      nonfinancial disclosure for this study.Informed consent was taken from 
      participants and available if requested.
EDAT- 2019/03/29 06:00
MHDA- 2019/03/29 06:01
PMCR- 2019/10/26
CRDT- 2019/03/29 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/09/27 00:00 [accepted]
PHST- 2019/03/29 06:00 [entrez]
PHST- 2019/03/29 06:00 [pubmed]
PHST- 2019/03/29 06:01 [medline]
PHST- 2019/10/26 00:00 [pmc-release]
AID - 359 [pii]
AID - 10.1007/s40200-018-0359-1 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2018 Oct 26;17(2):181-187. doi: 
      10.1007/s40200-018-0359-1. eCollection 2018 Dec.