PMID- 30923751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2405-6308 (Electronic)
IS  - 2405-6308 (Linking)
VI  - 16
DP  - 2019 May
TI  - Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) 
      patients treated with Stereotactic Body Radiation Therapy (SBRT).
PG  - 28-33
LID - 10.1016/j.ctro.2019.01.003 [doi]
AB  - *This study reports on the prognostic ability of haematological parameters for 
      the largest known biopsy-proven stage-I medically inoperable cohort treated with 
      SBRT.*After SBRT, the median values of Hb, ALC, ANC and TPC declined whereas the 
      NLR and the PLR increased as compared to pre-SBRT.*Anemia along with other 
      parameters was found to be a poor prognostic factor for local control despite 
      treatment with SBRT to doses of >100 Gy BED(10).*Simple and minimally invasive 
      methods like a peripheral blood sample can provide prognostic information even 
      for stage-I NSCLC patients.*Patient, tumor and treatment factors along with 
      molecular markers should be used to create risk stratification models that can 
      guide therapy.
FAU - Pathak, Rima S
AU  - Pathak RS
AD  - Division of Radiation Oncology, The University of Ottawa, Ottawa, ON, The Ottawa 
      Hospital Cancer Centre, Canada.
FAU - Pantarotto, Jason R
AU  - Pantarotto JR
AD  - Division of Radiation Oncology, The University of Ottawa, Ottawa, ON, The Ottawa 
      Hospital Cancer Centre, Canada.
FAU - Cook, Graham
AU  - Cook G
AD  - Division of Radiation Oncology, The University of Ottawa, Ottawa, ON, The Ottawa 
      Hospital Cancer Centre, Canada.
FAU - Holmes, Oliver
AU  - Holmes O
AD  - Discipline of Oncology, Dr. H. Bliss Murphy Cancer Centre, St. John's, 
      Newfoundland and Labrador, Canada.
FAU - Cross, Peter
AU  - Cross P
AD  - Division of Radiation Oncology, The University of Ottawa, Ottawa, ON, The Ottawa 
      Hospital Cancer Centre, Canada.
FAU - MacRae, Robert M
AU  - MacRae RM
AD  - Division of Radiation Oncology, The University of Ottawa, Ottawa, ON, The Ottawa 
      Hospital Cancer Centre, Canada.
LA  - eng
PT  - Journal Article
DEP - 20190124
PL  - Ireland
TA  - Clin Transl Radiat Oncol
JT  - Clinical and translational radiation oncology
JID - 101713416
PMC - PMC6423348
EDAT- 2019/03/30 06:00
MHDA- 2019/03/30 06:01
PMCR- 2019/01/24
CRDT- 2019/03/30 06:00
PHST- 2019/01/03 00:00 [received]
PHST- 2019/01/09 00:00 [accepted]
PHST- 2019/03/30 06:00 [entrez]
PHST- 2019/03/30 06:00 [pubmed]
PHST- 2019/03/30 06:01 [medline]
PHST- 2019/01/24 00:00 [pmc-release]
AID - S2405-6308(18)30120-4 [pii]
AID - 10.1016/j.ctro.2019.01.003 [doi]
PST - epublish
SO  - Clin Transl Radiat Oncol. 2019 Jan 24;16:28-33. doi: 10.1016/j.ctro.2019.01.003. 
      eCollection 2019 May.