PMID- 30924848
OWN - NLM
STAT- MEDLINE
DCOM- 20190823
LR  - 20200309
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 60
IP  - 4
DP  - 2019 Mar 1
TI  - Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients 
      With Inherited Retinal Degenerations.
PG  - 1234-1243
LID - 10.1167/iovs.18-25688 [doi]
AB  - PURPOSE: To determine whether high-resolution retinal imaging measures of macular 
      structure correlate with visual function over 36 months in retinal degeneration 
      (RD) patients and normal subjects. METHODS: Twenty-six eyes of 16 RD patients and 
      16 eyes of 8 normal subjects were studied at baseline; 15 eyes (14 RD) and 11 
      eyes (6 normal) were studied 36 months later. Adaptive Optics Scanning Laser 
      Ophthalmoscopy (AOSLO) was used to identify regions of interest (ROIs) with 
      unambiguous cones at baseline to measure cone spacing. AOSLO images were aligned 
      with spectral-domain optical coherence tomography (SD-OCT) and fundus-guided 
      microperimetry results to correlate structure and function at the ROIs. SD-OCT 
      images were segmented to measure inner segment (IS) and outer segment (OS) 
      thickness. Correlations between cone spacing, IS and OS thickness and sensitivity 
      were assessed using Spearman correlation coefficient rho with bootstrap analyses 
      clustered by person. RESULTS: Cone spacing (rho = 0.57, P < 0.001) and macular 
      sensitivity (rho = 0.19, P = 0.14) were significantly correlated with eccentricity 
      in patients. Controlling for eccentricity, cone spacing Z-scores were inversely 
      correlated with IS (rho = -0.29, P = 0.002) and OS thickness (rho = -0.39, P < 0.001) 
      in RD patients only, and with sensitivity in normal subjects (rho = -0.22, P < 
      0.001) and RD patients (rho = -0.38, P < 0.001). After 36 months, cone spacing 
      increased (P < 0.001) and macular sensitivity decreased (P = 0.007) compared to 
      baseline in RD patients. CONCLUSIONS: Cone spacing increased and macular 
      sensitivity declined significantly in RD patients over 36 months. High resolution 
      images of cone structure correlated with retinal sensitivity, and may be 
      appropriate outcome measures for clinical trials in RD.
FAU - Foote, Katharina G
AU  - Foote KG
AD  - School of Optometry and Vision Science Graduate Group, University of California, 
      Berkeley, Berkeley, California, United States.
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - De la Huerta, Irina
AU  - De la Huerta I
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - Gustafson, Kevin
AU  - Gustafson K
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - Baldwin, Angela
AU  - Baldwin A
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - Zayit-Soudry, Shiri
AU  - Zayit-Soudry S
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - Rinella, Nicholas
AU  - Rinella N
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
FAU - Porco, Travis C
AU  - Porco TC
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
AD  - Francis I. Proctor Foundation, University of California, San Francisco, 
      California, United States.
FAU - Roorda, Austin
AU  - Roorda A
AD  - School of Optometry and Vision Science Graduate Group, University of California, 
      Berkeley, Berkeley, California, United States.
FAU - Duncan, Jacque L
AU  - Duncan JL
AD  - Ophthalmology, University of California, San Francisco, California, United 
      States.
LA  - eng
GR  - P30 EY002162/EY/NEI NIH HHS/United States
GR  - R01 EY023591/EY/NEI NIH HHS/United States
GR  - T32 EY007043/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy/methods
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Cone Photoreceptor Cells/*pathology
MH  - Retinal Degeneration/*diagnosis/diagnostic imaging/physiopathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
PMC - PMC6440525
EDAT- 2019/03/30 06:00
MHDA- 2019/08/24 06:00
PMCR- 2019/03/01
CRDT- 2019/03/30 06:00
PHST- 2019/03/30 06:00 [entrez]
PHST- 2019/03/30 06:00 [pubmed]
PHST- 2019/08/24 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 2729835 [pii]
AID - IOVS-18-25688R1 [pii]
AID - 10.1167/iovs.18-25688 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1234-1243. doi: 
      10.1167/iovs.18-25688.