PMID- 30925760
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20201019
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 7
DP  - 2019 Mar 28
TI  - Contribution of Inflammatory Cytokine Interleukin-18 Genotypes to Renal Cell 
      Carcinoma.
LID - 10.3390/ijms20071563 [doi]
LID - 1563
AB  - Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development 
      and progression of many types of infectious and inflammatory diseases. In this 
      study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma 
      (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 
      (G/C). Moreover, we analyzed their interactions with smoking, alcohol drinking, 
      hypertension, and diabetes status. The results showed an association of the AC 
      and CC genotypes of IL-18 -607 with a significant decrease in the risk of RCC 
      compared with the AA genotype (odds ratio (OR) = 0.44 and 0.35, 95% confidence 
      interval (CI) = 0.27(-)0.72 and 0.18(-)0.66, p = 0.0008 and 0.0010, respectively). 
      Furthermore, a significantly lower frequency of the C allele at -607 was observed 
      in the RCC group (35.3% vs. 49.8%; OR = 0.53; 95% CI = 0.35(-)0.71, p = 0.0003). 
      However, IL-18 -656 and -137 did not exhibit a likewise differential distribution 
      of these genotypes between the control and case groups. Stratifying the 
      population according to smoking, alcohol drinking, hypertension, and diabetes 
      status revealed a different distribution of IL-18 -607 genotypes among 
      non-smokers, non-drinkers, and patients without diabetes, but not among smokers, 
      drinkers, or patients with diabetes. These findings suggest that IL-18 -607 
      genotypes may play a role in the etiology and progression of RCC in Taiwan and 
      may serve as a useful biomarker for early detection.
FAU - Chang, Wen-Shin
AU  - Chang WS
AD  - Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, 
      China Medical University Hospital, Taichung 40447, Taiwan. 
      halittlemelon@hotmail.com.
FAU - Shen, Te-Chun
AU  - Shen TC
AD  - Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, 
      China Medical University Hospital, Taichung 40447, Taiwan. chestshen@gmail.com.
FAU - Yeh, Wei-Lan
AU  - Yeh WL
AUID- ORCID: 0000-0003-4398-7610
AD  - Institute of New Drug Development, China Medical University, Taichung 40402, 
      Taiwan. wlyeh@mail.cmu.edu.tw.
FAU - Yu, Chien-Chih
AU  - Yu CC
AD  - School of Pharmacy, China Medical University, Taichung 40402, Taiwan. 
      ccyu@mail.cmu.edu.tw.
FAU - Lin, Hui-Yi
AU  - Lin HY
AD  - School of Pharmacy, China Medical University, Taichung 40402, Taiwan. 
      hylin@mail.cmu.edu.tw.
FAU - Wu, Hsi-Chin
AU  - Wu HC
AD  - Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, 
      China Medical University Hospital, Taichung 40447, Taiwan. wuhc@mail.cmuh.org.tw.
AD  - School of Medicine, China Medical University, Taichung 40402, Taiwan. 
      wuhc@mail.cmuh.org.tw.
FAU - Tsai, Chia-Wen
AU  - Tsai CW
AD  - Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, 
      China Medical University Hospital, Taichung 40447, Taiwan. wenwen816@gmail.com.
FAU - Bau, Da-Tian
AU  - Bau DT
AD  - Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, 
      China Medical University Hospital, Taichung 40447, Taiwan. artbau2@gmail.com.
AD  - Graduate Institute of Biomedical Sciences, China Medical University, Taichung 
      40402, Taiwan. artbau2@gmail.com.
AD  - Department of Bioinformatics and Medical Engineering, Asia University, Taichung 
      41354, Taiwan. artbau2@gmail.com.
LA  - eng
GR  - DMR107-175/China Medical University Hospital/
PT  - Journal Article
DEP - 20190328
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
MH  - Aged
MH  - Carcinoma, Renal Cell/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Kidney Neoplasms/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Taiwan/epidemiology
PMC - PMC6479470
OTO - NOTNLM
OT  - IL-18
OT  - Taiwan
OT  - genotype
OT  - polymorphism
OT  - renal cell carcinoma
COIS- The authors declare no conflict of interest.
EDAT- 2019/03/31 06:00
MHDA- 2019/07/30 06:00
PMCR- 2019/04/01
CRDT- 2019/03/31 06:00
PHST- 2019/01/14 00:00 [received]
PHST- 2019/03/26 00:00 [revised]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/03/31 06:00 [entrez]
PHST- 2019/03/31 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - ijms20071563 [pii]
AID - ijms-20-01563 [pii]
AID - 10.3390/ijms20071563 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Mar 28;20(7):1563. doi: 10.3390/ijms20071563.