PMID- 30926373 OWN - NLM STAT- MEDLINE DCOM- 20200128 LR - 20200128 IS - 1879-0542 (Electronic) IS - 0165-2478 (Linking) VI - 209 DP - 2019 May TI - The role of ocular dendritic cells in uveitis. PG - 4-10 LID - S0165-2478(18)30436-X [pii] LID - 10.1016/j.imlet.2019.03.016 [doi] AB - Dendritic cells (DCs) act as a bridge between innate and adoptive immunity. They are widely distributed in various tissues and organs. Resident ocular DCs are found in the peripheral margins and juxtapapillary areas of the retina, usually in an immature state. During inflammation, DCs are activated and participate in the development of uveitis, an ocular inflammatory disease. Herein, the characteristics and status of DCs in uveitis, the possible factors affecting the status of DCs, and the clinical methods for detecting the DCs in patients are described. CI - Copyright (c) 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. FAU - Lin, Wei AU - Lin W AD - Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China; Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, China. Electronic address: Linw1978@163.com. FAU - Liu, Tingting AU - Liu T AD - Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, 250021, China. FAU - Wang, Beibei AU - Wang B AD - Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China. FAU - Bi, Hongsheng AU - Bi H AD - Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China. Electronic address: bihongsheng0815@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20190326 PL - Netherlands TA - Immunol Lett JT - Immunology letters JID - 7910006 RN - 0 (Biomarkers) SB - IM MH - Animals MH - Biomarkers MH - Cell Communication/immunology MH - Dendritic Cells/*immunology/*metabolism MH - *Disease Susceptibility MH - Humans MH - Immunophenotyping MH - Phenotype MH - T-Lymphocytes/immunology/metabolism MH - Uveitis/*etiology/*metabolism/pathology OTO - NOTNLM OT - Confocal microscopy OT - Dendritic cells OT - T cells OT - Uveitis EDAT- 2019/03/31 06:00 MHDA- 2020/01/29 06:00 CRDT- 2019/03/31 06:00 PHST- 2018/10/03 00:00 [received] PHST- 2019/03/19 00:00 [revised] PHST- 2019/03/25 00:00 [accepted] PHST- 2019/03/31 06:00 [pubmed] PHST- 2020/01/29 06:00 [medline] PHST- 2019/03/31 06:00 [entrez] AID - S0165-2478(18)30436-X [pii] AID - 10.1016/j.imlet.2019.03.016 [doi] PST - ppublish SO - Immunol Lett. 2019 May;209:4-10. doi: 10.1016/j.imlet.2019.03.016. Epub 2019 Mar 26.