PMID- 30927123
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20211204
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 34
IP  - 1
DP  - 2020 Jan
TI  - Nutritional safety of oncometabolic surgery for early gastric cancer patients: a 
      prospective single-arm pilot study using a historical control group for 
      comparison.
PG  - 275-283
LID - 10.1007/s00464-019-06763-5 [doi]
AB  - BACKGROUND: Oncometabolic surgery (OS) is a modification of the Roux-en Y 
      reconstruction method, in which the lengths of the biliopancreatic and Roux limbs 
      are longer than that with conventional surgery (CS). Although OS is performed to 
      improve postoperative glycemic control in gastric cancer patients with type 2 
      diabetes mellitus (T2DM), its postoperative nutritional safety has not been 
      clarified. This prospective pilot study evaluated the safety and feasibility of 
      OS in early gastric cancer patients. METHODS: This study evaluated 20 patients 
      with clinical T1N0 stage and preoperative body mass index (BMI) >/= 32.5 kg/m(2), 
      or >/= 27.5 kg/m(2) with comorbidities, who underwent OS. Primary outcomes were 
      cumulative incidences of anemia and deficiencies in iron and vitamin B12 after 
      1 year. The outcomes were compared to those of a matched historical control 
      group. RESULTS: The cumulative incidences of anemia (15.0% vs. 10.0%, P = 0.99), 
      iron deficiency (15.0% vs. 10.0%, P = 0.99), and vitamin B12 deficiency (10.0% 
      vs. 0%, P = 0.47) did not differ significantly in the OS and CS groups. However, 
      median vitamin B12 concentration tended to be lower (395.8 vs. 493.7 pg/mL, 
      P = 0.06) and reductions in vitamin B12 concentration tended to be greater (174.7 
      vs. 123.0 pg/mL, P = 0.07) in the OS group. BMI loss was similar in the two 
      groups (2.9 vs. 2.8 kg/m(2), P = 0.80). Remission rates of hypertension (68.8% 
      vs. 41.2%, P = 0.22) and T2DM (77.8% vs. 50.0%, P = 0.58) were higher in the OS 
      group. CONCLUSION: Nutritional parameters did not differ significantly in the OS 
      and CS groups. Vitamin B12 levels should be carefully monitored after OS.
FAU - Park, Young Suk
AU  - Park YS
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Park, Do Joong
AU  - Park DJ
AUID- ORCID: 0000-0001-9644-6127
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea. 
      dojoongpark@gmail.com.
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Republic of Korea. dojoongpark@gmail.com.
FAU - Kim, Ki Hyun
AU  - Kim KH
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Park, Dong Jin
AU  - Park DJ
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Lee, Yoontaek
AU  - Lee Y
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Park, Ki Bum
AU  - Park KB
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Min, Sa-Hong
AU  - Min SH
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Ahn, Sang-Hoon
AU  - Ahn SH
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
FAU - Kim, Hyung-Ho
AU  - Kim HH
AD  - Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, 
      Bundang-gu, Seongnam-Si, Kyeonggi-do, 13620, Republic of Korea.
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190329
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - 0 (Blood Glucose)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - *Anastomosis, Roux-en-Y/adverse effects/methods
MH  - *Anemia/diagnosis/etiology/metabolism
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2/complications/metabolism
MH  - Female
MH  - *Gastric Bypass/adverse effects/methods
MH  - Humans
MH  - *Iron/metabolism
MH  - Iron Deficiencies
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pilot Projects
MH  - *Postoperative Complications/diagnosis/etiology/metabolism
MH  - Prospective Studies
MH  - *Stomach Neoplasms/complications/metabolism/pathology/surgery
MH  - *Vitamin B 12 Deficiency/diagnosis/etiology
OTO - NOTNLM
OT  - Metabolic syndrome
OT  - Nutritional status
OT  - Obesity
OT  - Reconstructive surgical procedures
OT  - Stomach neoplasm
EDAT- 2019/03/31 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/03/31 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/03/31 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/03/31 06:00 [entrez]
AID - 10.1007/s00464-019-06763-5 [pii]
AID - 10.1007/s00464-019-06763-5 [doi]
PST - ppublish
SO  - Surg Endosc. 2020 Jan;34(1):275-283. doi: 10.1007/s00464-019-06763-5. Epub 2019 
      Mar 29.