PMID- 30928248
OWN - NLM
STAT- MEDLINE
DCOM- 20200519
LR  - 20200519
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 45
IP  - 6
DP  - 2019 Dec
TI  - Coexistence of hyper-uricaemia and low urinary uric acid excretion further 
      increases risk of chronic kidney disease in type 2 diabetes.
PG  - 557-563
LID - S1262-3636(19)30058-8 [pii]
LID - 10.1016/j.diabet.2019.03.001 [doi]
AB  - AIM: To investigate whether hyper-uricaemia and decreased urinary uric acid 
      excretion (UUAE) are associated with increased risk of chronic kidney disease 
      (CKD), and whether the coexistence of hyper-uricaemia and low UUAE further 
      increases CKD risk in type 2 diabetes mellitus (T2DM). METHODS: In this 
      cross-sectional study based on serum uric acid (SUA) and UUAE levels, 2846 T2DM 
      inpatients were divided into those with normal SUA and UUAE (group 1), normal SUA 
      and low UUAE (group 2), hyper-uricaemia and normal UUAE (group 3), and 
      hyper-uricaemia and low UUAE (group 4). Hyper-uricaemia was defined as SUA 
      levels >/= 420 mumol/L in men and >/= 360 mumol/L in women. Low UUAE was defined as 
      levels below the first UUAE quintiles (< 2161 mumol/24 h in men, 1977 mumol/24 h in 
      women). RESULTS: There were trends for significantly increased prevalences of CKD 
      (4.3%, 12.6%, 18.3%, 47.8%; P < 0.001), albuminuria (20.2%, 26.4%, 36.9%, 54.9%; 
      P < 0.001) and macroalbuminuria (3.3%, 10.1%, 10.7%, 31.9%; P < 0.001) from 
      groups 1 to 4, respectively. After controlling for multiple confounding factors, 
      prevalences of CKD (P < 0.001) and urinary albumin levels (P = 0.013) showed 
      significantly increasing trends, whereas eGFR levels were markedly decreased from 
      groups 1 to 4 (P < 0.001). CONCLUSION: Hyper-uricaemia and low UUAE levels are 
      closely associated with presence of CKD, and the concomitant presence of 
      hyper-uricaemia and decreased UUAE levels further increased CKD risk in T2DM. 
      Thus, the combined consideration of SUA and UUAE levels may help to identify 
      those T2DM patients at higher CKD risk.
CI  - Copyright (c) 2019 Elsevier Masson SAS. All rights reserved.
FAU - Chen, M-Y
AU  - Chen MY
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China.
FAU - Wang, A-P
AU  - Wang AP
AD  - Department of Endocrinology, 454, Hospital of PLA, Nanjing 210002, Jiangsu 
      Province, PR China.
FAU - Wang, J-W
AU  - Wang JW
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China.
FAU - Ke, J-F
AU  - Ke JF
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China.
FAU - Yu, T-P
AU  - Yu TP
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China.
FAU - Li, L-X
AU  - Li LX
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China. Electronic address: 
      lilx@sjtu.edu.cn.
FAU - Jia, W-P
AU  - Jia WP
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Centre for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Centre for Metabolic Disease, PR China. Electronic address: 
      wpjia@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190327
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Aged
MH  - Albuminuria/blood/complications/epidemiology/urine
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications/epidemiology/urine
MH  - Diabetic Nephropathies/blood/epidemiology/*etiology/urine
MH  - Female
MH  - Humans
MH  - Hyperuricemia/blood/*complications/epidemiology/urine
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Renal Insufficiency, Chronic/blood/epidemiology/*etiology/urine
MH  - Risk Factors
MH  - Uric Acid/*blood/*urine
OTO - NOTNLM
OT  - Albuminuria
OT  - Chronic kidney disease
OT  - Hyper-uricaemia
OT  - Serum uric acid
OT  - Type 2 diabetes mellitus
OT  - Urinary uric acid excretion
EDAT- 2019/04/01 06:00
MHDA- 2020/05/20 06:00
CRDT- 2019/04/01 06:00
PHST- 2018/11/24 00:00 [received]
PHST- 2019/03/17 00:00 [revised]
PHST- 2019/03/17 00:00 [accepted]
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2020/05/20 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
AID - S1262-3636(19)30058-8 [pii]
AID - 10.1016/j.diabet.2019.03.001 [doi]
PST - ppublish
SO  - Diabetes Metab. 2019 Dec;45(6):557-563. doi: 10.1016/j.diabet.2019.03.001. Epub 
      2019 Mar 27.