PMID- 30928484
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 30
IP  - 7
DP  - 2019 Jul
TI  - Quantification of Blood Flow in Dialysis Access Using Custom-Acquisition Protocol 
      and Imaging Methods: A Clinical Validation Study.
PG  - 1062-1068.e2
LID - S1051-0443(18)31640-3 [pii]
LID - 10.1016/j.jvir.2018.10.023 [doi]
AB  - PURPOSE: To determine access blood flow (ABF) rate using 2D image sequences 
      acquired with digital subtraction angiography (DSA) and fluoroscopy. MATERIALS 
      AND METHODS: A total of 23 patients with known or suspected malfunctioning 
      accesses were imaged using 2 filming modes: DSA at 3 or 6 frames/s (F/s), and 
      fluoroscopy at 10 or 15 pulses/s (P/s). ABF rates were quantified using a bolus 
      tracking method based on cross-correlation algorithm and compared with 
      catheter-based thermal dilution (TD) flow measurements. The indicator-dilution 
      curves were fitted with a gamma-variate (GV) curve fitting model to assess the 
      effect on accuracy. Radiation doses were calculated to examine any increased 
      susceptibility to tissue reactions and stochastic effects. RESULTS: For DSA 
      images, the absolute percent deviations (mean +/- standard error of mean) in 
      computed flow vs TD flow measurements at 3 F/s and 6 F/s were 34% +/- 4.5% and 20% 
      +/- 4.7%, respectively, without curve fitting, and 31% +/- 3.3% and 20% +/- 4.1%, 
      respectively, with curve fitting. For fluoroscopic images, the deviations at 10 
      P/s and 15 P/s were 44% +/- 7.3% and 68% +/- 10.7%, respectively, without curve 
      fitting and 36% +/- 6.4% and 48% +/- 7.1%, respectively, with curve fitting. The mean 
      peak skin dose and effective dose at 6 F/s were 3.28 mGy and 75 muSv, 
      respectively. CONCLUSIONS: Digital subtraction angiography images obtained at 6 
      F/s offered the highest accuracy for dialysis access blood flow quantification.
CI  - Copyright (c) 2018 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Koirala, Nischal
AU  - Koirala N
AD  - Department of Chemical and Biomedical Engineering, Cleveland State University, 
      Cleveland, OH; Department of Biomedical Engineering, Cleveland Clinic, 9500 
      Euclid Ave, Cleveland, OH 44195.
FAU - Chauhan, Nikunj
AU  - Chauhan N
AD  - Section of Vascular and Interventional Radiology, Cleveland Clinic, 9500 Euclid 
      Ave, Cleveland, OH 44195.
FAU - Thompson, Dustin
AU  - Thompson D
AD  - Section of Vascular and Interventional Radiology, Cleveland Clinic, 9500 Euclid 
      Ave, Cleveland, OH 44195.
FAU - Karimloo, Zahra
AU  - Karimloo Z
AD  - Section of Vascular and Interventional Radiology, Cleveland Clinic, 9500 Euclid 
      Ave, Cleveland, OH 44195.
FAU - Wunderle, Kevin
AU  - Wunderle K
AD  - Section of Medical Physics, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 
      44195.
FAU - McLennan, Gordon
AU  - McLennan G
AD  - Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Ave, 
      Cleveland, OH 44195; Section of Vascular and Interventional Radiology, Cleveland 
      Clinic, 9500 Euclid Ave, Cleveland, OH 44195. Electronic address: 
      mclenng@ccf.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Validation Study
DEP - 20190327
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Angiography, Digital Subtraction/*methods
MH  - *Arteriovenous Shunt, Surgical
MH  - Blood Flow Velocity
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/diagnostic imaging/physiopathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Regional Blood Flow
MH  - *Renal Dialysis
MH  - Reproducibility of Results
MH  - Thermodilution
MH  - Time Factors
MH  - *Vascular Patency
EDAT- 2019/04/01 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/04/01 06:00
PHST- 2018/08/25 00:00 [received]
PHST- 2018/10/23 00:00 [revised]
PHST- 2018/10/23 00:00 [accepted]
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
AID - S1051-0443(18)31640-3 [pii]
AID - 10.1016/j.jvir.2018.10.023 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2019 Jul;30(7):1062-1068.e2. doi: 
      10.1016/j.jvir.2018.10.023. Epub 2019 Mar 27.