PMID- 30928539
OWN - NLM
STAT- MEDLINE
DCOM- 20200526
LR  - 20200804
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 25
IP  - 6
DP  - 2019 Jun
TI  - Myocardial Contraction Fraction Predicts Cardiovascular Events in Patients With 
      Hypertrophic Cardiomyopathy and Normal Ejection Fraction.
PG  - 450-456
LID - S1071-9164(19)30317-3 [pii]
LID - 10.1016/j.cardfail.2019.03.016 [doi]
AB  - BACKGROUND: Myocardial contraction fraction (MCF), the ratio of left ventricular 
      stroke volume to myocardial volume, is a novel parameter that can distinguish 
      between pathologic and physiologic hypertrophy. However, its prognostic value in 
      hypertrophic cardiomyopathy (HCM) has never been examined. The objective was to 
      determine if MCF is associated with functional capacity and predicts adverse 
      cardiovascular outcomes in patients with HCM and normal left ventricular ejection 
      fraction (LVEF). METHODS AND RESULTS: We conducted a prospective cohort study of 
      137 patients with HCM and LVEF >/=55%. Patients were followed for 2.7 +/- 2.5 years. 
      We examined association of MCF with New York Heart Association (NYHA) functional 
      class and a composite outcome of embolic stroke, heart transplantation, and 
      cardiac death. We performed time-to-event analysis with the use of Cox 
      proportional hazards modeling and stepwise elimination. The average age was 52 +/- 
      18 years. The average MCF was 26 +/- 11%. MCF was inversely correlated with NYHA 
      functional class (P = .001). A total of 20 subjects experienced an outcome event 
      with an event rate of 5.6% per patient-year. MCF independently predicted the 
      outcome (adjusted hazard ratio 0.50 per 10% increase, 95% confidence interval 
      0.28-0.90, adjusted P = .02). CONCLUSIONS: In patients with HCM and normal LVEF, 
      MCF is associated with functional capacity and independently predicts adverse 
      cardiovascular outcomes.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Shimada, Yuichi J
AU  - Shimada YJ
AD  - Division of Cardiology, Department of Medicine, Columbia University Medical 
      Center, New York, New York; Cardiology Division, Department of Medicine, 
      Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 
      Electronic address: ys3053@cumc.columbia.edu.
FAU - Hoeger, Christopher W
AU  - Hoeger CW
AD  - Division of Cardiology, Department of Medicine, Columbia University Medical 
      Center, New York, New York.
FAU - Latif, Farhana
AU  - Latif F
AD  - Division of Cardiology, Department of Medicine, Columbia University Medical 
      Center, New York, New York.
FAU - Takayama, Hiroo
AU  - Takayama H
AD  - Division of Cardiothoracic Surgery, Department of Surgery, Columbia University 
      Medical Center, New York, New York.
FAU - Ginns, Jonathan
AU  - Ginns J
AD  - Division of Cardiology, Department of Medicine, Columbia University Medical 
      Center, New York, New York.
FAU - Maurer, Mathew S
AU  - Maurer MS
AD  - Division of Cardiology, Department of Medicine, Columbia University Medical 
      Center, New York, New York.
LA  - eng
GR  - K24 AG036778/AG/NIA NIH HHS/United States
GR  - T35 AG044303/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20190328
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*mortality/physiopathology
MH  - Cohort Studies
MH  - *Death
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke Volume/*physiology
PMC - PMC7395217
MID - NIHMS1603156
OTO - NOTNLM
OT  - Hypertrophic cardiomyopathy
OT  - left ventricular ejection fraction
OT  - myocardial contraction fraction
OT  - prognosis
EDAT- 2019/04/01 06:00
MHDA- 2020/05/27 06:00
PMCR- 2020/08/01
CRDT- 2019/04/01 06:00
PHST- 2018/06/18 00:00 [received]
PHST- 2018/12/10 00:00 [revised]
PHST- 2019/03/21 00:00 [accepted]
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2020/05/27 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
PHST- 2020/08/01 00:00 [pmc-release]
AID - S1071-9164(19)30317-3 [pii]
AID - 10.1016/j.cardfail.2019.03.016 [doi]
PST - ppublish
SO  - J Card Fail. 2019 Jun;25(6):450-456. doi: 10.1016/j.cardfail.2019.03.016. Epub 
      2019 Mar 28.