PMID- 30928570
OWN - NLM
STAT- MEDLINE
DCOM- 20191202
LR  - 20191202
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 495
DP  - 2019 Aug
TI  - High serum adipocyte fatty acid binding protein concentration linked with 
      increased aortic arterial stiffness in patients with type 2 diabetes.
PG  - 35-39
LID - S0009-8981(19)31734-6 [pii]
LID - 10.1016/j.cca.2019.03.1629 [doi]
AB  - BACKGROUND: Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine 
      that contributes to the development of metabolic disorder, type 2 diabetes 
      mellitus (T2DM) and atherosclerosis. We determined the correlation between serum 
      A-FABP and aortic stiffness in T2DM patients. METHODS: Fasting blood samples were 
      obtained from 156 patients with T2DM. Serum A-FABP concentration were determined 
      using a commercial enzyme immunoassay. Carotid-femoral pulse wave velocity 
      (cfPWV) was measured using SphygmoCor System, and cfPWV values of >10 m/s were 
      defined as high aortic stiffness. RESULTS: Sixty participants (38.4%) fell under 
      the high aortic stiffness group. This group, compared to the control group, 
      showed older age (P = .004), higher systolic blood pressure (P < .001), diastolic 
      blood pressure (P = .027), urine albumin-to-creatinine ratio (P = .003), serum 
      A-FABP (P < .001) and lower estimated glomerular filtration rate (P = .001). 
      After adjusting for factors significantly associated with aortic stiffness using 
      multivariable logistic regression analysis, serum A-FABP [OR = 1.029 
      (1.002-1.058), P = .039] was found to be an independent predictor of aortic 
      stiffness in T2DM patients. CONCLUSIONS: Serum A-FABP is positively correlated 
      with aortic arterial stiffness in patients with T2DM.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Tseng, Pei-Wei
AU  - Tseng PW
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan.
FAU - Hou, Jia-Sian
AU  - Hou JS
AD  - Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
FAU - Wu, Du-An
AU  - Wu DA
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Metabolism 
      and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic 
      address: despdu@yahoo.com.tw.
FAU - Hsu, Bang-Gee
AU  - Hsu BG
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Nephrology, 
      Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: 
      gee.lily@msa.hinet.net.
LA  - eng
PT  - Journal Article
DEP - 20190327
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (FABP4 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy/*physiopathology
MH  - Fatty Acid-Binding Proteins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Vascular Stiffness/drug effects
OTO - NOTNLM
OT  - Adipocyte fatty acid binding protein
OT  - Aortic stiffness
OT  - Carotid-femoral pulse wave velocity
OT  - Type 2 diabetes mellitus
EDAT- 2019/04/01 06:00
MHDA- 2019/12/04 06:00
CRDT- 2019/04/01 06:00
PHST- 2018/12/05 00:00 [received]
PHST- 2019/03/13 00:00 [revised]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
AID - S0009-8981(19)31734-6 [pii]
AID - 10.1016/j.cca.2019.03.1629 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2019 Aug;495:35-39. doi: 10.1016/j.cca.2019.03.1629. Epub 2019 
      Mar 27.