PMID- 30929057
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20210109
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 276
IP  - 7
DP  - 2019 Jul
TI  - Comparison of the clinical characteristics of bilateral and unilateral fungal 
      balls in Korea.
PG  - 1975-1980
LID - 10.1007/s00405-019-05408-6 [doi]
AB  - OBJECTIVE: Fungal rhinosinusitis occurs in different forms depending on race and 
      region. While allergic fungal rhinosinusitis is common in Caucasians, fungal ball 
      (FB) is more common in Asians. However, most cases are reported as unilateral, 
      and clinical data on bilateral FB (BFB) are rare. Therefore, the purpose of this 
      study was to analyze and to compare the clinical characteristics of BFB and 
      unilateral FB (UFB) in Koreans. METHODS: We retrospectively analyzed medical 
      records and computed tomography (CT) images of 434 patients diagnosed with FB. 
      The patients were divided into two groups: BFB and UFB. Demographic data, 
      multiple allergen simultaneous test including total or specific immunoglobulin E 
      (IgE) levels, symptoms, CT findings, treatment, and outcomes were analyzed. 
      RESULTS: Among the patients, 26 had BFB and 408 had UFB. Hypertension was noted 
      in 61.5% of the BFB and 39% of the UBF individuals (p = 0.023). While total IgE 
      levels were similar between the two groups, Dermatophagoides pteronyssinus 
      (p = 0.004), Cladosporium (p = 0.017), and Aspergillus-specific IgE positivity 
      (p = 0.025) were significantly higher in the BFB than in the UFB group. Not only 
      symptoms such as postnasal drip (p = 0.013), mucopurulent rhinorrhea (p = 0.009), 
      and foul odor (p = 0.037), but also sphenoid sinus involvement on CT images were 
      more common in the BFB than in the UFB group (p = 0.011). CONCLUSION: Patients 
      with BFB in Korea showed more common hypertension and symptoms of foul odor, 
      mucopurulent rhinorrhea, and postnasal drip with allergy positivity compared to 
      those with UFB. Therefore, understanding clinical characteristics of BFB will 
      allow clinicians to approach BFB more appropriately.
FAU - Ahn, Sang Hyeon
AU  - Ahn SH
AD  - Department of Otorhinolaryngology, Bundang Jesaeng General Hospital, Daejin 
      Medical Center, Seongnam, Korea.
AD  - Department of Medicine, The Graduate School of Yonsei University, Seoul, Korea.
FAU - Lee, Eun Jung
AU  - Lee EJ
AD  - Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Department of Clinical and Experimental Medicine, The Centre for Personalised 
      Medicine, Linkoping, Sweden.
FAU - Hong, Min Pyo
AU  - Hong MP
AD  - Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Shin, Geun Cheol
AU  - Shin GC
AD  - Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Kim, Kyung-Su
AU  - Kim KS
AD  - Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea. ydrhinol@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20190330
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Comorbidity
MH  - Disease Management
MH  - Female
MH  - *Fungi/classification/isolation & purification
MH  - Humans
MH  - Hypertension/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Mycoses/epidemiology/microbiology/therapy
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - *Rhinitis/epidemiology/microbiology/therapy
MH  - Risk Factors
MH  - *Sinusitis/epidemiology/microbiology/surgery/therapy
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - Aspergillus
OT  - Bilateral
OT  - Fungal ball
OT  - Fungal rhinosinusitis
OT  - Korea
EDAT- 2019/04/01 06:00
MHDA- 2019/11/05 06:00
CRDT- 2019/04/01 06:00
PHST- 2018/12/24 00:00 [received]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
AID - 10.1007/s00405-019-05408-6 [pii]
AID - 10.1007/s00405-019-05408-6 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2019 Jul;276(7):1975-1980. doi: 
      10.1007/s00405-019-05408-6. Epub 2019 Mar 30.