PMID- 30929061 OWN - NLM STAT- MEDLINE DCOM- 20201106 LR - 20201106 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 270 IP - 2 DP - 2020 Mar TI - Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder. PG - 169-181 LID - 10.1007/s00406-019-01007-y [doi] AB - Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (p < 0.003) with MDD patients showing significantly higher methylation levels. CpG 5-2-1 revealed a statistically significant difference between MDD and healthy controls and MDD and BD (p = 0.00003). Similar to the results of the methylation analysis a significant difference between MDD and healthy controls was found in BDNF serum levels (p = 0.002) with significantly lower BDNF serum levels in MDD compared to healthy controls. A difference between the samples from admission and discharge from hospital of both BDNF gene methylation and serum levels could not be detected in the present study and no influence of the BDNF val66met genotype on neither methylation nor BDNF serum level. FAU - Schroter, Katrin AU - Schroter K AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. FAU - Brum, Murielle AU - Brum M AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. FAU - Brunkhorst-Kanaan, Nathalie AU - Brunkhorst-Kanaan N AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. FAU - Tole, Franziska AU - Tole F AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. FAU - Ziegler, Christiane AU - Ziegler C AD - Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Domschke, Katharina AU - Domschke K AD - Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Reif, Andreas AU - Reif A AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. FAU - Kittel-Schneider, Sarah AU - Kittel-Schneider S AUID- ORCID: 0000-0003-3057-6150 AD - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt, Germany. Sarah.Kittel-Schneider@kgu.de. LA - eng PT - Journal Article DEP - 20190330 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Biomarkers/blood MH - Bipolar Disorder/*blood/genetics/therapy MH - Brain-Derived Neurotrophic Factor/*blood/genetics MH - CpG Islands MH - *DNA Methylation MH - Depressive Disorder, Major/*blood/genetics/therapy MH - Female MH - Humans MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Patient Admission MH - Patient Discharge MH - Promoter Regions, Genetic MH - Remission Induction OTO - NOTNLM OT - BDNF OT - Bipolar disorder OT - Fluid biomarker OT - Major depression OT - Risk gene EDAT- 2019/04/01 06:00 MHDA- 2020/11/11 06:00 CRDT- 2019/04/01 06:00 PHST- 2018/12/29 00:00 [received] PHST- 2019/03/22 00:00 [accepted] PHST- 2019/04/01 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2019/04/01 06:00 [entrez] AID - 10.1007/s00406-019-01007-y [pii] AID - 10.1007/s00406-019-01007-y [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2020 Mar;270(2):169-181. doi: 10.1007/s00406-019-01007-y. Epub 2019 Mar 30.