PMID- 30929319
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 28
IP  - 9
DP  - 2019 Sep
TI  - Beyond the lungs: Alpha-1 antitrypsin's potential role in human gestation.
PG  - 1257-1261
LID - 10.17219/acem/103668 [doi]
AB  - Alpha-1 antitrypsin (AAT) is an acute-phase protein with strong inhibitory 
      activity towards proteolytic enzymes, mainly elastase but also trypsin, 
      chymotrypsin and thrombin. The biological role of the protein and the effects of 
      its deficiency have been subjects of scientific research for years, yet in many 
      areas our knowledge remains incomplete. Alpha-1 antitrypsin deficiency (AATD), a 
      defect in AAT synthesis and functionality, is one of the most frequently 
      inherited genetic disorders among Caucasian populations. Its severe form is 
      characterized by very low serum levels of AAT, and it most often affects the 
      lungs (causing early-onset emphysema or chronic obstructive lung disease (COPD)) 
      and/or liver (leading to jaundice and liver cirrhosis in children and adults). 
      However, little is known about other possible clinical consequences of AAT 
      deficiency. We discuss AAT's potential role in mechanisms regulating human 
      fertility and gestation, with a particular emphasis on the clinical context and 
      on indications for AATD diagnostic testing.
FAU - Jezela-Stanek, Aleksandra
AU  - Jezela-Stanek A
AD  - Department of Genetics and Clinical Immunology, National Institute of 
      Tuberculosis and Lung Diseases, Warszawa, Poland.
FAU - Chorostowska-Wynimko, Joanna
AU  - Chorostowska-Wynimko J
AD  - Department of Genetics and Clinical Immunology, National Institute of 
      Tuberculosis and Lung Diseases, Warszawa, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical 
      University
JID - 101138582
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis
MH  - Lung
MH  - Pregnancy/*physiology
MH  - Pregnancy Complications/enzymology
MH  - Pulmonary Disease, Chronic Obstructive
MH  - alpha 1-Antitrypsin/*physiology
MH  - alpha 1-Antitrypsin Deficiency/*complications
OTO - NOTNLM
OT  - alpha-1 antitrypsin
OT  - alpha-1 antitrypsin deficiency
OT  - diagnosis
OT  - oocyte maturation
OT  - pregnancy
EDAT- 2019/04/01 06:00
MHDA- 2019/10/23 06:00
CRDT- 2019/04/01 06:00
PHST- 2019/04/01 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2019/04/01 06:00 [entrez]
AID - 10.17219/acem/103668 [doi]
PST - ppublish
SO  - Adv Clin Exp Med. 2019 Sep;28(9):1257-1261. doi: 10.17219/acem/103668.