PMID- 30930563
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 1011-6842 (Print)
IS  - 1011-6842 (Linking)
VI  - 35
IP  - 2
DP  - 2019 Mar
TI  - Outcomes of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary 
      Hypertension at a Single Center in Taiwan.
PG  - 153-164
LID - 10.6515/ACS.201903_35(2).20180904A [doi]
AB  - BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is classified 
      as group IV pulmonary hypertension. This study aimed to report our institutional 
      experience in managing CTEPH. METHODS: We prospectively collected the data of 23 
      patients diagnosed with CTEPH between August 2001 and August 2017 in Linkou Chang 
      Gung Memorial Hospital. Baseline characteristics including functional class (FC), 
      6-minute walk distance (6MWD), comorbidities, hematological and biochemical data, 
      echocardiography, cardiac catheterization, and selective pulmonary angiography 
      were recorded at diagnosis. All patients were referred to a cardiac surgeon for 
      pulmonary endarterectomy (PEA) assessment. RESULTS: The mean age at diagnosis was 
      48.4 +/- 16.1 years. Nineteen patients (83%) underwent PEA with mean postoperative 
      follow-up of 37.7 +/- 42.8 months. The in-hospital mortality rate of PEA was 11%. 
      The 1-, 2-, 3- and 5-year overall survival rates were 89%, 89%, 81%, and 50%, 
      respectively. After 3 months of PEA, all patients had improvements in FC, 6MWD 
      (from 326 +/- 62 to 420 +/- 63 m), B-type natriuretic peptide level (from 602 +/- 599 
      to 268 +/- 565 pg/mL), and systolic pulmonary artery pressure (from 79 +/- 19 to 48 +/- 
      19 mmHg). The patients with proximal disease (Jamieson type 1 or 2) had better 
      survival than those with distal disease (Jamieson type 3 or 4), but there was no 
      significant difference in mortality between FC III and IV. All of the four 
      patients who did not undergo PEA survived for more than 3 years. CONCLUSIONS: 
      Significant improvements in symptoms, functional capacity, and hemodynamics were 
      achieved in the CTEPH patients after PEA. However, the overall survival was still 
      unsatisfactory.
FAU - Chen, Yu-Jhou
AU  - Chen YJ
AD  - College of Medicine, Chang Gung University, Chang Gung Memorial Hospital.
FAU - Ho, Chien-Te
AU  - Ho CT
AD  - Department of Cardiology.
FAU - Tsai, Feng-Chun
AU  - Tsai FC
AD  - Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Lin, Chia-Pin
AU  - Lin CP
AD  - Department of Cardiology.
FAU - Hsu, Lung-An
AU  - Hsu LA
AD  - Department of Cardiology.
FAU - Wang, Chun-Li
AU  - Wang CL
AD  - Department of Cardiology.
FAU - Lee, Kuang-Tso
AU  - Lee KT
AD  - Department of Cardiology.
FAU - Ho, Wan-Jing
AU  - Ho WJ
AD  - Department of Cardiology.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Cardiol Sin
JT  - Acta Cardiologica Sinica
JID - 101687085
PMC - PMC6434418
OTO - NOTNLM
OT  - Functional class
OT  - Jamieson classification
OT  - Pulmonary endarterectomy
OT  - Pulmonary hypertension
OT  - Pulmonary vascular disease
EDAT- 2019/04/02 06:00
MHDA- 2019/04/02 06:01
PMCR- 2019/03/01
CRDT- 2019/04/02 06:00
PHST- 2019/04/02 06:00 [entrez]
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2019/04/02 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.6515/ACS.201903_35(2).20180904A [doi]
PST - ppublish
SO  - Acta Cardiol Sin. 2019 Mar;35(2):153-164. doi: 
      10.6515/ACS.201903_35(2).20180904A.