PMID- 30930835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Multiple Distinctive Demyelinating Lesions Caused by Eosinophilic Granulomatosis 
      With Polyangiitis: Case Report and Literature Review.
PG  - 213
LID - 10.3389/fneur.2019.00213 [doi]
LID - 213
AB  - Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare 
      rheumatic immune disease characterized by vasculitis of small- and medium-sized 
      blood vessels. Central nervous system (CNS) involvement frequently consists of 
      cerebrovascular disease; a manifestation with multiple demyelinating lesions has 
      never been reported in detail. This report describes a 38-year-old man, who 
      presented with progressive memory deterioration and underwent microsurgery; EGPA 
      was subsequently confirmed. Unique clinical and radiological features as well as 
      immunohistological outcomes and DNA sequencing revealed a potential 
      disease-associated human leukocyte antigen (HLA) type, and single-nucleotide 
      polymorphisms (SNPs) are described for this uncommon case. Although EGPA rarely 
      involves the CNS, this differential diagnosis should be considered when patients 
      present with a history of nasosinusitis, elevated eosinophil percentage, clinical 
      pulmonitis, and neurological manifestations. Microsurgery is necessary for 
      precise diagnosis and effective treatment.
FAU - Xu, Dingkang
AU  - Xu D
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Xu, Hongen
AU  - Xu H
AD  - Center for Precision Medicine, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Wang, Guoqing
AU  - Wang G
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Wei, Qingjie
AU  - Wei Q
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Lei, Shixiong
AU  - Lei S
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Gao, Qiang
AU  - Gao Q
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Center for Precision Medicine, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
AD  - School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Guo, Fuyou
AU  - Guo F
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
AD  - Key Laboratory of Neurosurgical Diseases, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China.
LA  - eng
PT  - Case Reports
DEP - 20190311
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6423896
OTO - NOTNLM
OT  - CNS involvement
OT  - DNA sequencing
OT  - EGPA
OT  - HLA
OT  - SNP
OT  - differential diagnosis
OT  - neurosurgery
EDAT- 2019/04/02 06:00
MHDA- 2019/04/02 06:01
PMCR- 2019/03/11
CRDT- 2019/04/02 06:00
PHST- 2019/01/18 00:00 [received]
PHST- 2019/02/19 00:00 [accepted]
PHST- 2019/04/02 06:00 [entrez]
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2019/04/02 06:01 [medline]
PHST- 2019/03/11 00:00 [pmc-release]
AID - 10.3389/fneur.2019.00213 [doi]
PST - epublish
SO  - Front Neurol. 2019 Mar 11;10:213. doi: 10.3389/fneur.2019.00213. eCollection 
      2019.