PMID- 30930893
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20211204
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Metabolic Regulation of Dendritic Cell Differentiation.
PG  - 410
LID - 10.3389/fimmu.2019.00410 [doi]
LID - 410
AB  - Dendritic cells (DCs) are important antigen-presenting cells (APCs) that play 
      essential roles in bridging innate and adaptive immune responses. Differentiation 
      stages of DC subsets from bone marrow progenitor cells have been well-defined 
      during the past decades. Features that distinguish DC progenitor cells from each 
      differentiation stages, related signaling pathways and transcription factors that 
      are crucial for DC lineage commitment have been well-elucidated in numerous 
      studies. Recently, growing evidence are showing that cellular metabolism, as one 
      of the most fundamental process of cells, has essential role in the modulation of 
      immune system. There have been multiple reports and reviews that focus on the 
      metabolic modulations on DC functions, however little attention had been paid to 
      the metabolic regulation of DC development and differentiation. In recent years, 
      increasing evidence suggests that metabolic regulations also exert significant 
      impact on DC differentiation, as well as on the homeostasis of tissue resident 
      DCs. The focus of this review is to summarize the findings from recent studies on 
      the metabolic regulation of DC differentiation and to discuss the impacts of the 
      three major aspects of metabolism on the processes of DC development and 
      differentiation, namely the changes in metabolic pathways, the molecular 
      signaling pathways that modulate cell metabolism, and the effects of metabolites 
      and nutrients. The aim of this review is to draw attentions to this important and 
      exciting research field where the effects of metabolic process and their 
      regulation in DC differentiation need to be further explored.
FAU - He, Zhimin
AU  - He Z
AD  - School of Medicine, Institute for Immunology, Tsinghua University, Beijing, 
      China.
AD  - Tsinghua-Peking Center for Life Science, Beijing, China.
FAU - Zhu, Xinyi
AU  - Zhu X
AD  - School of Medicine, Institute for Immunology, Tsinghua University, Beijing, 
      China.
FAU - Shi, Zhen
AU  - Shi Z
AD  - School of Medicine, Institute for Immunology, Tsinghua University, Beijing, 
      China.
FAU - Wu, Tao
AU  - Wu T
AD  - School of Medicine, Institute for Immunology, Tsinghua University, Beijing, 
      China.
FAU - Wu, Li
AU  - Wu L
AD  - School of Medicine, Institute for Immunology, Tsinghua University, Beijing, 
      China.
AD  - Tsinghua-Peking Center for Life Science, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190313
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Fatty Acids)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*physiology
MH  - Dendritic Cells/*metabolism
MH  - Fatty Acids/metabolism
MH  - Glycolysis/physiology
MH  - Homeostasis/physiology
MH  - Humans
MH  - Mitochondria/metabolism
MH  - Nutrients/metabolism
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC6424910
OTO - NOTNLM
OT  - cell differentiation
OT  - dendritic cell (DC)
OT  - fatty acid (FA)
OT  - glycolysis
OT  - mTOR pathway
OT  - metabolic regulation
OT  - mitochondria function
OT  - nutrients
EDAT- 2019/04/02 06:00
MHDA- 2020/06/20 06:00
PMCR- 2019/01/01
CRDT- 2019/04/02 06:00
PHST- 2018/09/15 00:00 [received]
PHST- 2019/02/15 00:00 [accepted]
PHST- 2019/04/02 06:00 [entrez]
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.00410 [doi]
PST - epublish
SO  - Front Immunol. 2019 Mar 13;10:410. doi: 10.3389/fimmu.2019.00410. eCollection 
      2019.