PMID- 30932864
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1929-0748 (Print)
IS  - 1929-0748 (Electronic)
IS  - 1929-0748 (Linking)
VI  - 8
IP  - 4
DP  - 2019 Apr 1
TI  - A Medication Synchronization Program and Blood Pressure Levels in a Community 
      Pharmacy: Protocol.
PG  - e12527
LID - 10.2196/12527 [doi]
LID - e12527
AB  - BACKGROUND: The lack of adherence to prescribed antihypertensive medication 
      occurs in 50% of patients and leads to poor health outcomes and increased medical 
      costs. Consistent use of antihypertensive medications among patients with 
      hypertension is essential to the reduction of short- and long-term cardiovascular 
      complications. Strategies to improve medication adherence include syncing 
      prescription medications in the pharmacy, which allow patients to retrieve 
      chronically prescribed medications in one visit. The adoption of medication 
      synchronization has been shown to improve adherence to medications; however, 
      there is a lack of data showing if the intervention reduces blood pressure and 
      improves long-term health outcomes. OBJECTIVE: This study aims to determine the 
      association between participation in an appointment-based medication 
      synchronization service and blood pressure levels among patients on 
      antihypertensive medications. METHODS: This longitudinal prospective cohort study 
      will observe changes in blood pressure among individuals in a medication 
      synchronization program and those in a usual care group. Patients on at least two 
      antihypertensive medications and four total medications have been recruited to 
      participate in the study. All participants will be required to have at least a 
      6-month history of filling prescriptions at the pharmacy prior to enrollment in 
      the study. Based on an estimated standard deviation of 14 mmHg, a sample size of 
      70 participants provides approximately 80% power with a two-sided .05 
      significance to detect a difference of 9 mmHg blood pressure between the two 
      cohorts. RESULTS: As of the publication of this paper, patients are completing 
      final blood pressure visits at the pharmacy and medication data are being 
      collected from the pharmacy. Once patients complete all blood pressure visits, 
      data analysis will begin. CONCLUSIONS: This study will link medication 
      synchronization and changes in blood pressure levels among individuals with 
      hypertension. This study will provide preliminary data for a randomized clinical 
      trial that will assess the impact of medication synchronization on blood 
      pressure. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): 
      DERR1-10.2196/12527.
CI  - (c)Anthony Pattin, Rebekah L Panak, Rebecca Hunold, Abagail Kirwen, Samantha R 
      Minnich, Tian Chen. Originally published in JMIR Research Protocols 
      (http://www.researchprotocols.org), 01.04.2019.
FAU - Pattin, Anthony
AU  - Pattin A
AUID- ORCID: 0000-0002-1404-9038
AD  - Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, 
      The University of Toledo, Toledo, OH, United States.
FAU - Panak, Rebekah L
AU  - Panak RL
AUID- ORCID: 0000-0002-5383-5760
AD  - Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, 
      The University of Toledo, Toledo, OH, United States.
FAU - Hunold, Rebecca
AU  - Hunold R
AUID- ORCID: 0000-0002-6740-4865
AD  - Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, 
      The University of Toledo, Toledo, OH, United States.
FAU - Kirwen, Abagail
AU  - Kirwen A
AUID- ORCID: 0000-0003-2766-5988
AD  - Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, 
      The University of Toledo, Toledo, OH, United States.
FAU - Minnich, Samantha R
AU  - Minnich SR
AUID- ORCID: 0000-0001-8202-2059
AD  - Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, 
      The University of Toledo, Toledo, OH, United States.
FAU - Chen, Tian
AU  - Chen T
AUID- ORCID: 0000-0003-2900-9087
AD  - Department of Mathematics and Statistics, College of Natural Science and 
      Mathematics, The University of Toledo, Toledo, OH, United States.
LA  - eng
PT  - Journal Article
DEP - 20190401
PL  - Canada
TA  - JMIR Res Protoc
JT  - JMIR research protocols
JID - 101599504
PMC - PMC6462886
OTO - NOTNLM
OT  - hypertension
OT  - medication synchronization
OT  - pharmacy practice
COIS- Conflicts of Interest: None declared.
EDAT- 2019/04/02 06:00
MHDA- 2019/04/02 06:01
PMCR- 2019/04/01
CRDT- 2019/04/02 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2018/12/21 00:00 [accepted]
PHST- 2018/12/03 00:00 [revised]
PHST- 2019/04/02 06:00 [entrez]
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2019/04/02 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - v8i4e12527 [pii]
AID - 10.2196/12527 [doi]
PST - epublish
SO  - JMIR Res Protoc. 2019 Apr 1;8(4):e12527. doi: 10.2196/12527.