PMID- 30933702 OWN - NLM STAT- MEDLINE DCOM- 20191230 LR - 20191230 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 275 DP - 2019 May TI - An examination of genes, stress and suicidal behavior in two First Nations communities: The role of the brain-derived neurotropic factor gene. PG - 247-252 LID - S0165-1781(17)31419-1 [pii] LID - 10.1016/j.psychres.2019.02.034 [doi] AB - Suicide claims over 800,000 lives each year worldwide. Suicide rates in indigenous populations in Canada are about double that of the national average, making it a serious public health issue. Numerous factors are involved in suicide risk, including genetic factors, as well as various psychosocial stressors, such as historical experience with the Indian Residential School system for Indigenous populations, as well as protective variables such as social support. Here, we report the first genetic study of suicidal behaviors that includes multiple measures of stress and social supports. We investigated the role of the functional Val66Met marker (rs6265) in the Brain-Derived Neurotropic Factor (BDNF) gene in suicidal ideation and suicide attempt in a First Nations community sample (N = 278). We did not find a significant association between the BDNF rs6265 marker and suicidal behaviors. We found childhood adversities, recent life stress, chronic stress, perceived stress, difficulties, and hazardous alcohol use to be associated with both suicidal ideation and suicide attempt. Thus, while additional studies with larger samples are required to elucidate the genetic component of suicide, addressing environmental stressors may be important for suicide prevention. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Zai, Clement C AU - Zai CC AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address: clement.zai@camh.ca. FAU - George, Julie AU - George J AD - Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada. FAU - Cheema, Sheraz Y AU - Cheema SY AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Zai, Gwyneth C AU - Zai GC AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. FAU - Fonseka, Trehani M AU - Fonseka TM AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada; St. Michael's Hospital, University Health Network, Toronto, ON, Canada. FAU - Danesi, Michael AU - Danesi M AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Shaikh, Sajid A AU - Shaikh SA AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Irwin, David AU - Irwin D AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Tampakeras, Maria AU - Tampakeras M AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Freeman, Natalie AU - Freeman N AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. FAU - Rehm, Jurgen AU - Rehm J AD - Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Wells, Samantha AU - Wells S AD - Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada; School of Psychology, Deakin University, Geelong, Australia. Electronic address: Samantha.wells@camh.ca. FAU - Kennedy, James L AU - Kennedy JL AD - Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address: jim.kennedy@camh.ca. LA - eng GR - CBG-101926/CIHR/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190218 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Brain-Derived Neurotrophic Factor/*analysis MH - Canada/epidemiology MH - Child MH - Female MH - Humans MH - Male MH - Population Groups/*psychology MH - Risk Factors MH - Schools MH - Social Support MH - Stress, Psychological/*ethnology/*genetics MH - Suicidal Ideation MH - Suicide, Attempted/*ethnology MH - Young Adult OTO - NOTNLM OT - Brain-derived neurotropic factor (BDNF) gene OT - First Nations OT - Genetics OT - Stress OT - Suicidal behavior OT - rs6265 Val66Met EDAT- 2019/04/02 06:00 MHDA- 2019/12/31 06:00 CRDT- 2019/04/02 06:00 PHST- 2017/08/10 00:00 [received] PHST- 2019/02/14 00:00 [revised] PHST- 2019/02/15 00:00 [accepted] PHST- 2019/04/02 06:00 [pubmed] PHST- 2019/12/31 06:00 [medline] PHST- 2019/04/02 06:00 [entrez] AID - S0165-1781(17)31419-1 [pii] AID - 10.1016/j.psychres.2019.02.034 [doi] PST - ppublish SO - Psychiatry Res. 2019 May;275:247-252. doi: 10.1016/j.psychres.2019.02.034. Epub 2019 Feb 18.