PMID- 30933773
OWN - NLM
STAT- MEDLINE
DCOM- 20190723
LR  - 20190723
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 249
DP  - 2019 Jun
TI  - Associations between concentrations of perfluoroalkyl substances in human plasma 
      and maternal, infant, and home characteristics in Winnipeg, Canada.
PG  - 758-766
LID - S0269-7491(19)30061-2 [pii]
LID - 10.1016/j.envpol.2019.03.054 [doi]
AB  - Perfluoroalkyl substances (PFASs) are known to be toxic, bioaccumulative, and 
      persistent. However, exposure routes and toxic effects to humans are still widely 
      unknown. Our objectives were to evaluate potential correlations between 
      concentrations of PFASs in maternal plasma and infant cord blood with home 
      characteristics and developmental effects, including wheezing. The concentrations 
      of 17 PFASs were measured in plasma from prenatal women (n = 414), postnatal 
      women (n = 247), and cord blood (n = 50) from a subset of participants in a 
      population-based birth cohort in Winnipeg, Manitoba, Canada, using online solid 
      phase extraction (SPE) with liquid chromatography coupled with tandem mass 
      spectrometry (LC-MS/MS). Multiple linear regression and principal component 
      analysis (PCA) were used to evaluate possible associations with PFAS 
      concentrations. Surveys were used to collect information regarding maternal 
      characteristics (e.g. age, parity, duration of breastfeeding), infant 
      characteristics (e.g. birth weight, birth length, head circumference, gestational 
      age, and incidence of recurrent wheezing), and home characteristics (e.g. home 
      age,carpet coverage in the most used room, presence of new furniture, or recent 
      home renovations). PFASs in plasma were associated with maternal characteristics 
      but not home characteristics or early childhood wheezing. PFASs were not 
      associated with developmental effects, with the exception that 
      perfluoroundecanoic acid (PFUA) was negatively associated with birth weight. 
      Further studies investigating the potential influences of PFUA on birth weight 
      are warranted.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Workman, Clare E
AU  - Workman CE
AD  - Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada. 
      Electronic address: clare.elizabeth.mc@gmail.com.
FAU - Becker, Allan B
AU  - Becker AB
AD  - Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada; 
      Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
FAU - Azad, Meghan B
AU  - Azad MB
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada.
FAU - Moraes, Theo J
AU  - Moraes TJ
AD  - Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Mandhane, Piush J
AU  - Mandhane PJ
AD  - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
FAU - Turvey, Stuart E
AU  - Turvey SE
AD  - Department of Pediatrics, Child & Family Research Institute, BC Children's 
      Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
FAU - Subbarao, Padmaja
AU  - Subbarao P
AD  - Department of Pediatrics & Physiology, Hospital for Sick Children, University of 
      Toronto, Toronto, Ontario, Canada.
FAU - Brook, Jeffrey R
AU  - Brook JR
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, 
      Canada.
FAU - Sears, Malcolm R
AU  - Sears MR
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
FAU - Wong, Charles S
AU  - Wong CS
AD  - Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada; 
      Department of Environmental Studies and Sciences, The University of Winnipeg, 
      Richardson College for the Environment, Winnipeg, Manitoba, Canada; Department of 
      Chemistry, The University of Winnipeg, Richardson College for the Environment, 
      Winnipeg, Manitoba, Canada.
LA  - eng
PT  - Journal Article
DEP - 20190321
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (perfluoroundecanoic acid)
MH  - *Child Development
MH  - Environmental Pollutants/*blood
MH  - Fatty Acids/blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Manitoba
MH  - Maternal Exposure/adverse effects/*statistics & numerical data
MH  - Pregnancy
OTO - NOTNLM
OT  - Blood
OT  - Developmental effects
OT  - Liquid chromatography
OT  - Perfluoroalkyl substances
EDAT- 2019/04/02 06:00
MHDA- 2019/07/25 06:00
CRDT- 2019/04/02 06:00
PHST- 2019/01/12 00:00 [received]
PHST- 2019/02/16 00:00 [revised]
PHST- 2019/03/13 00:00 [accepted]
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2019/04/02 06:00 [entrez]
AID - S0269-7491(19)30061-2 [pii]
AID - 10.1016/j.envpol.2019.03.054 [doi]
PST - ppublish
SO  - Environ Pollut. 2019 Jun;249:758-766. doi: 10.1016/j.envpol.2019.03.054. Epub 
      2019 Mar 21.