PMID- 30935324
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210507
IS  - 2042-6186 (Electronic)
IS  - 1066-9817 (Print)
IS  - 1066-9817 (Linking)
VI  - 28
IP  - 1
DP  - 2020 Feb
TI  - Effect of spinal manipulative therapy on mechanical pain sensitivity in patients 
      with chronic nonspecific low back pain: a pilot randomized, controlled trial.
PG  - 15-27
LID - 10.1080/10669817.2019.1572986 [doi]
AB  - Objectives: The long-term goal of our study is to improve the understanding of 
      the biological mechanisms associated with spinal manipulative therapy (SMT) in 
      low back pain.Methods: This project involved a pilot randomized, blinded clinical 
      trial (ClinicalTrials.gov registration number NCT03078114) of 3-week SMT in 
      chronic nonspecific low back pain (CNSLBP) patients. We recruited 29 participants 
      and randomly assigned them into either a SMT (n = 14) or sham SMT (n = 15) group. 
      Pre- and postintervention, we quantified the effect of SMT on clinical outcomes 
      (Numeric Pain Rating Scale and Oswestry Disability Index) and pressure pain 
      threshold (PPT) at local (lumbar spine), regional (lower extremity), and remote 
      (upper extremity) anatomical sites.Results: We observed a significant main effect 
      for time signifying reduced hypersensitivity (increased PPT) at local (p = .015) 
      and regional (p = .014) locations at 3 weeks. Furthermore, we found significant 
      main effects of time indicating improvements in pain (p < .001) and disability (p 
      = .02) from baseline among all participants regardless of intervention. However, 
      no between-group differences were observed in PPT, clinical pain, or disability 
      between the SMT and sham SMT groups over 3 weeks.Conclusions: After 3 weeks of 
      SMT or sham SMT in CNSLBP patients, we found hypoalgesia at local and remote 
      sites along with improved pain and low back-related disability.Level of Evidence: 
      1b.
FAU - Bond, Bryan M
AU  - Bond BM
AUID- ORCID: 0000-0003-2431-9801
AD  - Department of Physical Therapy, University of Saint Mary, Leavenworth, KS, USA.
FAU - Kinslow, Chris D
AU  - Kinslow CD
AD  - Department of Physical Therapy, University of Saint Mary, Leavenworth, KS, USA.
FAU - Yoder, Adam W
AU  - Yoder AW
AD  - Department of Physical Therapy, University of Saint Mary, Leavenworth, KS, USA.
FAU - Liu, Wen
AU  - Liu W
AD  - Department of Physical Therapy and Rehabilitation Science, University of Kansas 
      Medical Center, Kansas City, KS, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT03078114
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190305
PL  - England
TA  - J Man Manip Ther
JT  - The Journal of manual & manipulative therapy
JID - 9433812
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Low Back Pain/*physiopathology/*therapy
MH  - Male
MH  - Manipulation, Spinal/*methods
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - Pilot Projects
MH  - Single-Blind Method
MH  - Young Adult
PMC - PMC7006726
OTO - NOTNLM
OT  - Spinal manipulation
OT  - chronic
OT  - low back pain
OT  - lumbar spine
OT  - manual therapy
OT  - pressure pain threshold
OT  - treatment outcome
EDAT- 2019/04/03 06:00
MHDA- 2021/04/13 06:00
PMCR- 2020/03/05
CRDT- 2019/04/03 06:00
PHST- 2020/03/05 00:00 [pmc-release]
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2019/04/03 06:00 [entrez]
AID - 1572986 [pii]
AID - 10.1080/10669817.2019.1572986 [doi]
PST - ppublish
SO  - J Man Manip Ther. 2020 Feb;28(1):15-27. doi: 10.1080/10669817.2019.1572986. Epub 
      2019 Mar 5.