PMID- 30936143
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20200601
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 68
IP  - 6
DP  - 2019 Jun
TI  - Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance 
      in the Fat- and Fructose-Fed Dog.
PG  - 1143-1155
LID - 10.2337/db18-1209 [doi]
AB  - This study assessed the effectiveness of surgical sympathetic denervation of the 
      common hepatic artery (CHADN) in improving glucose tolerance. CHADN eliminated 
      norepinephrine content in the liver and partially decreased it in the pancreas 
      and the upper gut. We assessed oral glucose tolerance at baseline and after 4 
      weeks of high-fat high-fructose (HFHF) feeding. Dogs were then randomized to sham 
      surgery (SHAM) (n = 9) or CHADN surgery (n = 11) and retested 2.5 or 3.5 weeks 
      later while still on the HFHF diet. CHADN improved glucose tolerance by  approximately 60% in 
      part because of enhanced insulin secretion, as indicated by an increase in the 
      insulinogenic index. In a subset of dogs (SHAM, n = 5; CHADN, n = 6), a 
      hyperinsulinemic-hyperglycemic clamp was used to assess whether CHADN could 
      improve hepatic glucose metabolism independent of a change in insulin release. 
      CHADN reduced the diet-induced defect in net hepatic glucose balance by 37%. In 
      another subset of dogs (SHAM, n = 4; CHADN, n = 5) the HFHF diet was continued 
      for 3 months postsurgery and the improvement in glucose tolerance caused by CHADN 
      continued. In conclusion, CHADN has the potential to enhance postprandial glucose 
      clearance in states of diet-induced glucose intolerance.
CI  - (c) 2019 by the American Diabetes Association.
FAU - Kraft, Guillaume
AU  - Kraft G
AUID- ORCID: 0000-0001-8538-4725
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, TN guillaume.kraft@vanderbilt.edu.
FAU - Vrba, Anthony
AU  - Vrba A
AD  - Metavention, Eden Prairie, MN.
FAU - Scott, Melanie
AU  - Scott M
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, TN.
FAU - Allen, Eric
AU  - Allen E
AD  - Hormone Assay and Analytical Services Core, Vanderbilt University Medical Center, 
      Nashville, TN.
FAU - Edgerton, Dale S
AU  - Edgerton DS
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, TN.
AD  - Hormone Assay and Analytical Services Core, Vanderbilt University Medical Center, 
      Nashville, TN.
FAU - Williams, Phil E
AU  - Williams PE
AD  - Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN.
FAU - Vafai, Scott B
AU  - Vafai SB
AD  - Metavention, Eden Prairie, MN.
FAU - Azamian, Bobak R
AU  - Azamian BR
AD  - Metavention, Eden Prairie, MN.
FAU - Cherrington, Alan D
AU  - Cherrington AD
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, TN.
LA  - eng
GR  - P30 DK020593/DK/NIDDK NIH HHS/United States
GR  - R01 DK018243/DK/NIDDK NIH HHS/United States
GR  - U24 DK059637/DK/NIDDK NIH HHS/United States
GR  - U2C DK059637/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190401
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Dietary Sugars)
RN  - 30237-26-4 (Fructose)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - *Diet, High-Fat
MH  - *Dietary Sugars
MH  - Dogs
MH  - Fructose
MH  - Glucose Clamp Technique
MH  - Glucose Intolerance/*metabolism
MH  - Glucose Tolerance Test
MH  - Hepatic Artery/*innervation
MH  - Liver/*metabolism
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Pancreas/metabolism
MH  - Random Allocation
MH  - *Sympathectomy
MH  - Upper Gastrointestinal Tract/metabolism
PMC - PMC6610023
EDAT- 2019/04/03 06:00
MHDA- 2019/12/24 06:00
PMCR- 2020/06/01
CRDT- 2019/04/03 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/03/17 00:00 [accepted]
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/04/03 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - db18-1209 [pii]
AID - 1209 [pii]
AID - 10.2337/db18-1209 [doi]
PST - ppublish
SO  - Diabetes. 2019 Jun;68(6):1143-1155. doi: 10.2337/db18-1209. Epub 2019 Apr 1.