PMID- 30936734
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Prevalence of hypothyroidism in patients with type 2 diabetes mellitus and 
      hypertension in India: a cross-sectional observational study.
PG  - 369-376
LID - 10.2147/DMSO.S181470 [doi]
AB  - PURPOSE: To determine the prevalence of hypothyroidism in patients with type 2 
      diabetes mel-litus (T2DM), hypertension, and both T2DM and hypertension (T2DM + 
      hypertension) in India. PATIENTS AND METHODS: In this cross-sectional 
      observational study, adult patients with an established or newly diagnosed T2DM, 
      hypertension, and T2DM + hypertension who were visiting their physicians for a 
      routine clinical checkup were enrolled across 29 sites in India. All the 
      patient-related data were extracted from their medical records. The prevalence of 
      hypothyroidism was evaluated by thyroid function test (levels of serum free 
      thyroxine, free triiodothyronine, and thyroid-stimulating hormone [TSH]). The 
      proportion of obese and overweight hypothyroid patients and dose of thyroxine in 
      overt and subclinical hypothyroidism (SCH) cases (as per TSH values) were 
      assessed during the study. The results were summarized by descriptive statistics. 
      RESULTS: A total of 1,508 patients (T2DM: 504; hypertension: 501; T2DM + 
      hypertension: 503) were enrolled in the study. The prevalence of hypothyroidism 
      in patients with T2DM, hypertension, and T2DM + hypertension was 24.8%, 33.5%, 
      and 28.9%, respectively. The overall prevalence of hypothyroidism in T2DM 
      (n=1,002) and hypertension (n=1,001) was 26.9% and 31.2%, respectively. The 
      proportion of obese against overweight hypothyroid patients was higher in all 
      indications (T2DM: 16.5% vs 3.4%; hypertension: 23.8% vs 5.4%; T2DM + 
      hypertension: 21.5% vs 3.8%). A considerable proportion of patients with SCH was 
      prescribed thyroxine in T2DM (61.5%), hypertension (61%), and T2DM + hypertension 
      (62.5%) cases. The most commonly prescribed dose (mean) of thyroxine was 50 and 
      25 microg for overt hypothyroidism and SCH cases, respectively, in all cohorts. 
      CONCLUSION: There is a high (>20%) prevalence of hypothyroidism in patients with 
      T2DM, hypertension, and T2DM + hypertension. Screening for hypothyroidism should 
      be routinely considered for early diagnosis and effective management.
FAU - Talwalkar, Pradeep
AU  - Talwalkar P
AD  - Endocrinology, Talwalkar Diabetes Clinic, Mumbai, India.
FAU - Deshmukh, Vaishali
AU  - Deshmukh V
AD  - Endocrinology, Shree Hospital, Pune, India.
FAU - Bhole, Milind
AU  - Bhole M
AD  - Medical Affairs, Abbott India Ltd, Mumbai, India, mbhole170@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190320
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6431000
OTO - NOTNLM
OT  - hypertension
OT  - hypothyroidism
OT  - prevalence
OT  - type 2 diabetes mellitus
COIS- Disclosure Dr Talwalkar and Dr Deshmukh received research funding from Abbott 
      India Ltd. Dr Bhole is an employee of Abbott India Ltd. The authors report no 
      other conflicts of interest in this work.
EDAT- 2019/04/03 06:00
MHDA- 2019/04/03 06:01
PMCR- 2019/03/20
CRDT- 2019/04/03 06:00
PHST- 2019/04/03 06:00 [entrez]
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2019/04/03 06:01 [medline]
PHST- 2019/03/20 00:00 [pmc-release]
AID - dmso-12-369 [pii]
AID - 10.2147/DMSO.S181470 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Mar 20;12:369-376. doi: 10.2147/DMSO.S181470. 
      eCollection 2019.