PMID- 30937143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 12
IP  - 3
DP  - 2019
TI  - Gut microbial dysbiosis is associated with allergen-specific IgE responses in 
      young children with airway allergies.
PG  - 100021
LID - 10.1016/j.waojou.2019.100021 [doi]
LID - 100021
AB  - BACKGROUND: There is increasing evidence linking alterations of the gut microbial 
      composition during early infancy to the development of atopic diseases and 
      asthma. However, few studies have addressed the association of dysbiotic gut 
      microbiota with allergic reactions through evaluation of feces in young children 
      with allergic airway diseases. METHODS: We sought to evaluate relationships among 
      gut microbiota, total fecal immunoglobulin E (IgE) levels, serum allergic 
      sensitization, and their relevance to childhood allergic rhinitis and asthma. 
      Microbial composition and diversity were analyzed with Illumina-based 16S rRNA 
      gene sequencing of 89 stool samples collected from children with asthma (n = 35) 
      and allergic rhinitis (n = 28), and from healthy controls (n = 26). Data analysis 
      was performed using Quantitative Insights into Microbial Ecology (QIIME) 
      software. RESULTS: A significantly lower abundance of organisms of the phylum 
      Firmicutes were found in children with asthma and allergic rhinitis than in the 
      healthy controls. Relatively lower Chao1 and Shannon indices were also found in 
      children with allergic airway diseases but without any significant difference. 
      Total fecal IgE levels in early childhood were strongly correlated with serum 
      D. pteronyssinus- and D. farinae-specific IgE but not with food-specific IgE 
      levels. In comparison with healthy controls, the genus Dorea was less abundant 
      and negatively correlated with total fecal IgE levels in children with rhinitis, 
      whereas the genus Clostridium was abundant and positively correlated with fecal 
      IgE levels in children with asthma. CONCLUSIONS: An interaction between 
      particular subsets of gut microbial dysbiosis and IgE-mediated responses to 
      allergens may contribute to the susceptibility to allergic rhinitis and asthma in 
      early childhood.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Chang Gung 
      University, Taoyuan, Taiwan.
AD  - Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial 
      Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
FAU - Chan, Yi-Ling
AU  - Chan YL
AD  - Department of Emergency Medicine, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan.
AD  - Clinical Informatics and Medical Statistics Research Center, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Tsai, Ming-Han
AU  - Tsai MH
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Wang, Chia-Jung
AU  - Wang CJ
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Chiang, Meng-Han
AU  - Chiang MH
AD  - Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chiu, Chun-Che
AU  - Chiu CC
AD  - Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial 
      Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20190325
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC6439417
OTO - NOTNLM
OT  - Asthma
OT  - Clostridium spp.
OT  - Dorea spp.
OT  - Fecal IgE
OT  - Gut microbiota
OT  - IgE, immunoglobulin E
OT  - OTUs, Operational taxonomic Units
OT  - QIIME, Quantitative Insights into Microbial Ecology
EDAT- 2019/04/03 06:00
MHDA- 2019/04/03 06:01
PMCR- 2019/03/25
CRDT- 2019/04/03 06:00
PHST- 2018/10/26 00:00 [received]
PHST- 2019/01/02 00:00 [revised]
PHST- 2019/01/29 00:00 [accepted]
PHST- 2019/04/03 06:00 [entrez]
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2019/04/03 06:01 [medline]
PHST- 2019/03/25 00:00 [pmc-release]
AID - S1939-4551(19)30109-7 [pii]
AID - 100021 [pii]
AID - 10.1016/j.waojou.2019.100021 [doi]
PST - epublish
SO  - World Allergy Organ J. 2019 Mar 25;12(3):100021. doi: 
      10.1016/j.waojou.2019.100021. eCollection 2019.