PMID- 30937828
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 14
IP  - 5
DP  - 2020 Oct
TI  - Longitudinal fMRI task reveals neural plasticity in default mode network with 
      disrupted executive-default coupling and selective attention after traumatic 
      brain injury.
PG  - 1638-1650
LID - 10.1007/s11682-019-00094-8 [doi]
AB  - Executive dysfunctions are common in individuals with Traumatic Brain Injury 
      (TBI). However, change in functional neural coupling of default and executive 
      networks in the post-acute phase (>/= 1 month after injury) patients over time has 
      yet to be understood. During a 5-week observation period, we examined changes in 
      the goal-oriented executive function networks in 20 TBI participants, using a 
      face/scene matching 1-back fMRI task (Chen et al. 2011). We conducted 
      multivariate pattern analysis to assess working memory and visual selective 
      attention, followed by a repeat-measures ANOVA to examine longitudinal changes, 
      with a cluster FDR at p = .001. Results showed that task accuracy significantly 
      improved after follow-up. Significantly increased activity patterns over time 
      were observed in the right dorsolateral prefrontal cortex and right insula. 
      Decreased activity patterns were seen in the left posterior cingulate cortex 
      (PCC), bilateral precuneus, right inferior occipital gyrus and right 
      temporo-occipital junction. Improvement in task accuracy correlated with 
      decreased activity patterns in the PCC (r = -0.478, p = 0.031) and 
      temporo-occipital junction (r = -0.592, p = 0.006), which were interpreted as 
      neural plastic changes. However, we did not observe the default mode network 
      (DMN)-executive network decoupling during task performance that is found in other 
      studies. These results suggest that fMRI of attentional task performance could 
      serve as a potential biomarker for neural plasticity of selective attention in 
      TBI patients in the post-acute phase.
FAU - Wu, Shun-Chin Jim
AU  - Wu SJ
AD  - National Defense Medical Center, School of Medicine, Taipei, Taiwan.
FAU - Jenkins, Lisanne M
AU  - Jenkins LM
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, Chicago, IL, USA.
FAU - Apple, Alexandra C
AU  - Apple AC
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, Chicago, IL, USA.
FAU - Petersen, Julie
AU  - Petersen J
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, Chicago, IL, USA.
FAU - Xiao, Furen
AU  - Xiao F
AD  - National Taiwan University Hospital, Taipei, Taiwan.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, Chicago, IL, USA.
FAU - Yang, Fan-Pei Gloria
AU  - Yang FG
AD  - Center for Cognition & Mind Science, National Tsinghua University, No. 101, 
      Section 2, Kuang-Fu Road, Hsinchu, Taiwan, 30013. hbmyang@gmail.com.
LA  - eng
GR  - NSC 103-2420-H-007-004-MY2/Ministry of Science and Technology, Taiwan/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Attention
MH  - Brain/diagnostic imaging
MH  - *Brain Injuries, Traumatic/diagnostic imaging
MH  - Brain Mapping
MH  - Default Mode Network
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Nerve Net
MH  - Neuronal Plasticity
OTO - NOTNLM
OT  - Executive function
OT  - Machine learning
OT  - Multivariate
OT  - Plasticity
OT  - Working memory
EDAT- 2019/04/03 06:00
MHDA- 2021/04/28 06:00
CRDT- 2019/04/03 06:00
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2019/04/03 06:00 [entrez]
AID - 10.1007/s11682-019-00094-8 [pii]
AID - 10.1007/s11682-019-00094-8 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2020 Oct;14(5):1638-1650. doi: 10.1007/s11682-019-00094-8.