PMID- 30938257
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2578-5826 (Electronic)
IS  - 2578-5826 (Linking)
VI  - 41
IP  - 1
DP  - 2018 Mar
TI  - Inhaled steroid inhibits development of total and mite IgE.
PG  - 17-22
LID - 10.1080/09114300.2018.1451599 [doi]
AB  - Serum levels of total immunoglobulin E (IgE) and allergen-specific IgE are 
      related to asthma severity and risk factors for persistent asthma in childhood 
      wheezing. Inhaled corticosteroids (ICS) have been the most effective therapy in 
      children with asthma, as well as in adults. The serum levels of total and mite 
      specific IgE in children with asthma and the effects on IgE levels of 
      beclomethasone dipropionate (BDP) treatment on IgE levels in asthmatic children 
      were investigated. First, a cross-sectional study of 255 children with asthma was 
      carried out to measure IgE levels. Children under three years of age with asthma 
      who were negative for Df-specific IgE were then treated with BDP or disodium 
      cromoglycate (DSCG) as controls for one year. Serum IgE levels, numbers of 
      eosinophils in peripheral blood and clinical variables were determined before and 
      after treatment. After one-year DSCG treatment, the total IgE levels increased 
      significantly, whereas the levels remained the same during BDP treatment. Five of 
      22 (23%) patients in the DSCG-treated group became positive for Df-specific IgE; 
      however, only one of 13 (8%) in the BDP-treated group became positive. Taken 
      together, ICS therapy may modulate the levels of total IgE and allergen-specific 
      IgE.
FAU - Murayama, Norihide
AU  - Murayama N
AUID- ORCID: 0000-0002-6608-6391
AD  - a Department of Pediatrics , Osaka Prefectural Medical Center for Respiratory and 
      Allergy Diseases , Habikino , Japan.
AD  - b Department of Pediatrics , Murayama Pediatrics , Osaka , Japan.
FAU - Doi, Satoru
AU  - Doi S
AD  - a Department of Pediatrics , Osaka Prefectural Medical Center for Respiratory and 
      Allergy Diseases , Habikino , Japan.
FAU - Inoue, Toshishige
AU  - Inoue T
AD  - c Department of Pediatrics , Sumitomo Hospital , Osaka , Japan.
FAU - Takamatsu, Isamu
AU  - Takamatsu I
AD  - a Department of Pediatrics , Osaka Prefectural Medical Center for Respiratory and 
      Allergy Diseases , Habikino , Japan.
FAU - Kameda, Makoto
AU  - Kameda M
AD  - a Department of Pediatrics , Osaka Prefectural Medical Center for Respiratory and 
      Allergy Diseases , Habikino , Japan.
FAU - Takeda, Katsuyuki
AU  - Takeda K
AUID- ORCID: 0000-0003-1623-3573
AD  - d Department of Pediatrics , National Jewish Medical and Research Center , Denver 
      , CO , USA.
FAU - Toyoshima, Kyoichiro
AU  - Toyoshima K
AD  - a Department of Pediatrics , Osaka Prefectural Medical Center for Respiratory and 
      Allergy Diseases , Habikino , Japan.
LA  - eng
PT  - Journal Article
DEP - 20180403
PL  - England
TA  - Immunol Med
JT  - Immunological medicine
JID - 101736847
OTO - NOTNLM
OT  - Development of IgE
OT  - childhood asthma
OT  - infantile wheezing
OT  - inhaled steroid
EDAT- 2019/04/03 06:00
MHDA- 2019/04/03 06:01
CRDT- 2019/04/03 06:00
PHST- 2019/04/03 06:00 [entrez]
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2019/04/03 06:01 [medline]
AID - 10.1080/09114300.2018.1451599 [doi]
PST - ppublish
SO  - Immunol Med. 2018 Mar;41(1):17-22. doi: 10.1080/09114300.2018.1451599. Epub 2018 
      Apr 3.