PMID- 30939601
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20200603
IS  - 1439-1899 (Electronic)
IS  - 0174-304X (Linking)
VI  - 50
IP  - 4
DP  - 2019 Aug
TI  - Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter 
      Injury in Newborns.
PG  - 228-234
LID - 10.1055/s-0038-1677516 [doi]
AB  - Recent reports have suggested an association between rotavirus infection and a 
      distinctive pattern of white matter injury (WMI) in neonates with seizures; 
      however, the connection between the two is not fully understood. To evaluate the 
      underlying mechanism, we profiled and compared eight cytokines (IL 
      [interleukin]-1beta, IL-6, IL-8, IL-10, IFN-gamma [interferon-gamma ], MCP-1 [monocyte 
      chemoattractant protein-1], MIP-1beta [macrophage inflammatory protein-1beta], and 
      TNF-alpha [tumor necrosis factor-alpha]) in the cerebrospinal fluid (CSF) of 33 neonates 
      with seizures who had no other well-known causes of seizures and 13 control 
      patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 
      neonates with seizures, 9 showed WMI and all were infected with rotavirus 
      (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus 
      (R + W - ) and 13 were not (R - W - ).Only MCP-1 and MIP-1beta were different 
      between the groups. MCP-1 was increased in R+ W+ compared with R + W- (p < 0.01), 
      R - W- (p < 0.01), and control (p = 0.03) patients. MIP-1beta was decreased in 
      R + W+ compared with R - W- (p < 0.01) and control (p < 0.01), but not R + W- 
      (p = 0.23) patients. MCP-1 and MIP-1beta are C-C chemokines that recruit immune 
      cells to the site of inflammation. Our pilot study suggests MCP-1-mediated 
      monocyte recruitment may be linked with this complication caused by rotavirus.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Yeom, Jung Sook
AU  - Yeom JS
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Jo, Jae-Young
AU  - Jo JY
AD  - Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Park, Ji Sook
AU  - Park JS
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Kim, Young-Soo
AU  - Kim YS
AD  - Department of Neurology, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
FAU - Chung, Ju-Young
AU  - Chung JY
AD  - Department of Pediatrics, Sanggyepaik Hospital, Inje University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Han, Tae-Hee
AU  - Han TH
AD  - Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, Inje 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Seo, Ji-Hyun
AU  - Seo JH
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Park, Eun Sil
AU  - Park ES
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Lim, Jae-Young
AU  - Lim JY
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Woo, Hyang-Ok
AU  - Woo HO
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Youn, Hee-Shang
AU  - Youn HS
AD  - Department of Pediatrics, Gyeongsang National University School of Medicine, 
      Jinju, Republic of Korea.
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Park, Chan-Hoo
AU  - Park CH
AD  - Gyeongsang Institute of Health Science, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
AD  - Department of Pediatrics, Changwon Gyeongsang National University Hospital, 
      Changwon, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190402
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
SB  - IM
MH  - Brain/*diagnostic imaging/virology
MH  - Chemokine CCL2/*cerebrospinal fluid
MH  - Cytokines/cerebrospinal fluid
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Leukoencephalopathies/*cerebrospinal fluid/diagnostic imaging/virology
MH  - Male
MH  - Rotavirus
MH  - Rotavirus Infections/*complications/diagnostic imaging
MH  - White Matter/*diagnostic imaging/virology
COIS- The authors declare that there is no conflict of interest.
EDAT- 2019/04/03 06:00
MHDA- 2020/06/04 06:00
CRDT- 2019/04/03 06:00
PHST- 2019/04/03 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
PHST- 2019/04/03 06:00 [entrez]
AID - 10.1055/s-0038-1677516 [doi]
PST - ppublish
SO  - Neuropediatrics. 2019 Aug;50(4):228-234. doi: 10.1055/s-0038-1677516. Epub 2019 
      Apr 2.