PMID- 30939896
OWN - NLM
STAT- MEDLINE
DCOM- 20200701
LR  - 20200701
IS  - 1466-1799 (Electronic)
IS  - 0007-1668 (Linking)
VI  - 60
IP  - 3
DP  - 2019 Jun
TI  - Both experimental hypo- and hyper-thyroidism exacerbate the adverse effects of 
      chronic heat stress in broilers.
PG  - 330-339
LID - 10.1080/00071668.2019.1602248 [doi]
AB  - 1. The effects of hypo- and hyper-thyroidism in mitigating or exacerbating the 
      negative changes of chronic heat stress (HS) in broilers were investigated.2. 
      Three-week-old broilers were distributed into six groups (n = 13 per group). 
      Three groups were housed at ambient room temperature: control group (CN), 
      propylthiouracil-treated group (AN) and thyroxine-treated group (TN). The other 
      three groups were exposed to HS at 33 +/- 1 degrees C for 2 weeks: control heat stress 
      (CH), propylthiouracil + heat stress (AH) and thyroxine + HS (TH).3. Induced 
      hypothyroidy significantly decreased cloacal temperature and body weight gain in 
      the birds in both the normal and HS groups (AN, AH). Conversely, hyperthyroidy 
      resulted in a significant elevation in cloacal temperature in the TN and TH 
      groups and a significant decline in weight gain in the TH group. Hyperthyroidy 
      exacerbated the HS-induced degenerative changes in jejunal mucosa and caused 
      noticeable vascular changes. A significant increase in the expression levels of 
      jejunal nutrient transporter genes was observed in the AH and TH groups. The 
      hyperthyroidic state significantly upregulated the HSP70 expression level in the 
      TH group and the reverse occurred with propylthiouracil (PTU) treatment in the AH 
      group.4. PTU supplementation to chicks reared under HS significantly decreased 
      the triiodothyronine level, antibody (Ab) titre, and increased the 
      heterophil-lymphocyte ratio. Furthermore, it induced higher hepatic glutathione 
      peroxidase (GSH-Px) activity in the AN and AH groups and decreased the 
      malondialdehyde content (MDA) in the AN group. Hyperthyroidy significantly 
      increased triiodothyronine concentration, H/L ratio and decreased Hb 
      concentration and Ab titres in the TH group. Additionally, this status increased 
      the MDA content and decreased the GSH-Px activities.5. In conclusion, 
      manipulation of thyroid status is not a remedy to overcome the undesirable 
      effects of HS in broilers.
FAU - Al Wakeel, R A
AU  - Al Wakeel RA
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
FAU - Saad, M F
AU  - Saad MF
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
FAU - Abdel Azeez, A
AU  - Abdel Azeez A
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
FAU - Elkhiat, F
AU  - Elkhiat F
AD  - Department of Poultry Diseases, Faculty of Veterinary Medicine, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
FAU - Shukry, M
AU  - Shukry M
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190501
PL  - England
TA  - Br Poult Sci
JT  - British poultry science
JID - 15740290R
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - *Chickens
MH  - Heat Stress Disorders/*veterinary
MH  - Heat-Shock Response
MH  - Hot Temperature
MH  - Malondialdehyde
OTO - NOTNLM
OT  - Blood variables
OT  - GLUT2
OT  - PEPT1
OT  - PTU
OT  - heat stress
OT  - hyperthyroidism
EDAT- 2019/04/04 06:00
MHDA- 2020/07/02 06:00
CRDT- 2019/04/04 06:00
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2020/07/02 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
AID - 10.1080/00071668.2019.1602248 [doi]
PST - ppublish
SO  - Br Poult Sci. 2019 Jun;60(3):330-339. doi: 10.1080/00071668.2019.1602248. Epub 
      2019 May 1.