PMID- 30940777
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 4
DP  - 2019 Apr 30
TI  - Anti-depressant effects of oil from fructus gardeniae via PKA-CREB-BDNF 
      signaling.
LID - BSR20190141 [pii]
LID - 10.1042/BSR20190141 [doi]
AB  - The dried ripe fruit of Gardenia jasminoides Ellis was usually applied as an herb 
      medicine in Traditional Chinese Medicine. It was suggested that the Gardenia 
      jasminoides oil extract (oil from Fructus Gardeniae [OFG]) might serve as a 
      potential treatment for depression, whereas its pathogenesis still remained not 
      fully understood. The present research was conducted to evaluate the 
      anti-depressive effect of OFG in mice and explore its potential mechanism. The 
      OFG and ketamine (KET) were intragastrically and intraperitoneally treated, 
      respectively. Thereafter, the animals were subjected to the behavior tests. The 
      expressions of protein kinase A (PKA), brain derived neurotrophic factor (BDNF), 
      cAMP response element-binding protein (CREB) in hippocampus were detected by 
      Western blot. The selective PKA inhibitor H-89 was also applied to confirm the 
      mechanism. As a result, OFG and KET treatment improved the behavior performance. 
      Furthermore, the administrations of OFG effectively enhanced the expressions of 
      PKA, p-CREB, and BDNF. With the application of selective PKA inhibitor H-89, the 
      ameliorated effects caused by OFG were blocked, but not by KET. In conclusion, 
      the presented work indicated that OFG-exerted protective effect on depression 
      through PKA-CREB-BDNF signaling.
CI  - (c) 2019 The Author(s).
FAU - Ruan, Jie
AU  - Ruan J
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 211198, China.
FAU - Liu, Li
AU  - Liu L
AD  - Guangdong Medical University, Dongguan 523808, China.
FAU - Shan, Xin
AU  - Shan X
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 211198, China.
FAU - Xia, Baomei
AU  - Xia B
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 211198, China.
FAU - Fu, Qiang
AU  - Fu Q
AUID- ORCID: 0000-0002-1416-8336
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 211198, China qiangfucpu@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190426
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Isoquinolines)
RN  - 0 (Plant Oils)
RN  - 0 (Sulfonamides)
RN  - 690G0D6V8H (Ketamine)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - M876330O56 (N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cyclic AMP Response Element-Binding Protein/*genetics
MH  - Cyclic AMP-Dependent Protein Kinases/*genetics
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Fruit/chemistry
MH  - Gardenia/*chemistry
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects
MH  - Isoquinolines/pharmacology
MH  - Ketamine/pharmacology
MH  - Medicine, Chinese Traditional
MH  - Mice
MH  - Plant Oils/chemistry/pharmacology
MH  - Plants, Medicinal/chemistry
MH  - Sulfonamides/pharmacology
PMC - PMC6487269
OTO - NOTNLM
OT  - Depression
OT  - Gardenia jasminoides oil extract
OT  - PKA/CREB/BDNF
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/04/04 06:00
MHDA- 2020/04/21 06:00
PMCR- 2019/04/26
CRDT- 2019/04/04 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/03/19 00:00 [revised]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
PHST- 2019/04/26 00:00 [pmc-release]
AID - BSR20190141 [pii]
AID - 10.1042/BSR20190141 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Apr 26;39(4):BSR20190141. doi: 10.1042/BSR20190141. Print 2019 
      Apr 30.