PMID- 30941320
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2288-6575 (Print)
IS  - 2288-6796 (Electronic)
IS  - 2288-6575 (Linking)
VI  - 96
IP  - 4
DP  - 2019 Apr
TI  - Nomogram for accurate prediction of breast and axillary pathologic response after 
      neoadjuvant chemotherapy in node positive patients with breast cancer.
PG  - 169-176
LID - 10.4174/astr.2019.96.4.169 [doi]
AB  - PURPOSE: Many patients with cytology proven node-positive breast cancer receive a 
      neoadjuvant chemotherapy (NAC) treatment. We developed a nomogram to predict the 
      breast and axillary pathologic complete responses (pCR) in patients with a 
      cytologically proven axillary node positive breast cancer with NAC. METHODS: We 
      selected 995 patients who were diagnosed with an invasive breast cancer and 
      axillary lymph nodes metastasis, and who were treated with NAC followed by a 
      curative surgery at the Samsung Medical Center between January 2007 and December 
      2014. The baseline patient and tumor characteristics, chemotherapy regimen, and 
      tumor and nodal responses were thoroughly analyzed and reviewed. A nomogram was 
      developed using a binary logistic regression model with a cross validation. 
      RESULTS: Axillary pCR was achieved in 47.3% and breast pCR was achieved in 24.3% 
      of the patients after NAC. In this case, the both pCR was associated with an 
      initial clinical tumor stage, negative progesterone receptor status, positive 
      human epidermal growth factor receptor 2 status, and clinical radiologic nodal 
      responses. A nomogram was developed based on the clinical and statistically 
      significant predictors. It had good discrimination performance (area under the 
      curve [AUC], 0.868; 95% confidence interval, 0.84-0.89) and calibration fit as 
      noted in that case. The cross validation had an average AUC 0.853 (0.837-0.869). 
      CONCLUSION: Our nomogram might help to predict breast and axillary pCRs after NAC 
      in patients with an initially node-positive breast cancer. Minimal surgery might 
      be acceptable in patients for whom the nomogram indicates a high probability of 
      achieving pCRs.
FAU - Choi, Hee Jun
AU  - Choi HJ
AD  - Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School 
      of Medicine, Changwon, Korea.
FAU - Ryu, Jai Min
AU  - Ryu JM
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, Isaac
AU  - Kim I
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Nam, Seok Jin
AU  - Nam SJ
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, Seok Won
AU  - Kim SW
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Yu, Jonghan
AU  - Yu J
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Jeong Eon
AU  - Lee JE
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Se Kyung
AU  - Lee SK
AUID- ORCID: 0000-0003-1630-1783
AD  - Division of Breast Surgery, Department of Surgery, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190328
PL  - Korea (South)
TA  - Ann Surg Treat Res
JT  - Annals of surgical treatment and research
JID - 101622895
PMC - PMC6444045
OTO - NOTNLM
OT  - Complete response
OT  - Neoadjuvant treatment
OT  - Nomograms
COIS- CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2019/04/04 06:00
MHDA- 2019/04/04 06:01
PMCR- 2019/04/01
CRDT- 2019/04/04 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/11/19 00:00 [revised]
PHST- 2018/12/11 00:00 [accepted]
PHST- 2019/04/04 06:00 [entrez]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2019/04/04 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.4174/astr.2019.96.4.169 [doi]
PST - ppublish
SO  - Ann Surg Treat Res. 2019 Apr;96(4):169-176. doi: 10.4174/astr.2019.96.4.169. Epub 
      2019 Mar 28.