PMID- 30941686
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20240213
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Linking)
VI  - 24
IP  - 4
DP  - 2020 Apr
TI  - Predictive Factors of Postoperative Delirium in Patients After 
      Pancreaticoduodenectomy.
PG  - 849-854
LID - 10.1007/s11605-019-04212-1 [doi]
AB  - BACKGROUND: Postoperative delirium is a common serious complication after various 
      types of surgery. However, the incidence and predictive factors associated with 
      delirium after pancreaticoduodenectomy (PD) have not been investigated. Thus, 
      this study aimed to investigate the incidence and predictive factors of 
      postoperative delirium in patients who underwent PD. METHODS: This study included 
      155 consecutive patients who underwent PD. Patients with and without 
      postoperative delirium were compared to identify differential patient 
      characteristics. Multivariate regression analysis was used to statistically 
      identify independent predictive factors significantly associated with the 
      development of postoperative delirium. RESULTS: Postoperative delirium developed 
      in 27 (22.4%) of 155 patients. The majority of incidents occurred on 
      postoperative day 2, and the mean delirium duration was 4.6 +/- 4.8 days. Patients 
      with postoperative delirium had an older age and a previous history of 
      benzodiazepine use. A multivariate analysis revealed that the development of 
      delirium was significantly correlated with these two factors. Receiver-operator 
      characteristics (ROC) curve analysis of the two factors yielded an area under the 
      ROC curve of 0.823 (0.750-0.896), suggesting good discrimination power. 
      CONCLUSIONS: This study reports on the incidence of postoperative delirium after 
      PD. Furthermore, we identified age and use of benzodiazepines as significant 
      predictive factors for developing delirium after PD. These results contribute to 
      the prediction and treatment of postoperative delirium.
FAU - Tomimaru, Yoshito
AU  - Tomimaru Y
AUID- ORCID: 0000-0002-4432-060X
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan. ytomimaru@gmail.com.
FAU - Park, Sung Ae
AU  - Park SA
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan.
FAU - Shibata, Asuka
AU  - Shibata A
AD  - Department of Psychiatry, Toyonaka Municipal Hospital, Toyonaka, Japan.
FAU - Miyagawa, Shinichi
AU  - Miyagawa S
AD  - Department of Psychiatry, Toyonaka Municipal Hospital, Toyonaka, Japan.
FAU - Noguchi, Kozo
AU  - Noguchi K
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan.
FAU - Noura, Shingo
AU  - Noura S
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan.
FAU - Imamura, Hiroshi
AU  - Imamura H
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan.
FAU - Shirakawa, Toru
AU  - Shirakawa T
AD  - Public Health, Department of Social Medicine, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Dono, Keizo
AU  - Dono K
AD  - Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, 
      Osaka, 560-8565, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190402
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
SB  - IM
MH  - Aged
MH  - *Delirium/diagnosis/epidemiology/etiology
MH  - Humans
MH  - Incidence
MH  - Pancreatectomy
MH  - *Pancreaticoduodenectomy/adverse effects
MH  - Postoperative Complications/epidemiology/etiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Delirium
OT  - Pancreaticoduodenectomy
OT  - Postoperative delirium
EDAT- 2019/04/04 06:00
MHDA- 2021/04/15 06:00
CRDT- 2019/04/04 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
AID - S1091-255X(23)01426-9 [pii]
AID - 10.1007/s11605-019-04212-1 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2020 Apr;24(4):849-854. doi: 10.1007/s11605-019-04212-1. 
      Epub 2019 Apr 2.