PMID- 30941725
OWN - NLM
STAT- MEDLINE
DCOM- 20191217
LR  - 20200309
IS  - 2092-9293 (Electronic)
IS  - 1976-9571 (Linking)
VI  - 41
IP  - 6
DP  - 2019 Jun
TI  - Transcriptome analysis for identifying possible causes of post-reproductive death 
      of Sepia esculenta based on brain tissue.
PG  - 629-645
LID - 10.1007/s13258-019-00811-z [doi]
AB  - BACKGROUND: The subpeduncle lobe/olfactory lobe-optic gland axis is called the 
      endocrine regulation center of cephalopods. However, little is known about the 
      mechanism of the subpeduncle lobe/olfactory lobe-optic gland axis regulate the 
      sexual maturation and post-reproductive death of Sepia esculenta Hoyle. 
      OBJECTIVES: The primary objective of this study was to provide basic information 
      for revealing the mechanism of the subpeduncle lobe/olfactory lobe-optic axis 
      regulating the rapid post-reproductive death of S. esculenta. METHODS: In this 
      paper, Illumina sequencing based transcriptome analysis was performed on the 
      brain tissue of female S. esculenta in the three key developmental stages: growth 
      stage (BG), spawning stage (BS), and post-reproductive death stage (BA). RESULTS: 
      A total of 66.19 Gb Illumina sequencing data were obtained. A comparative 
      analysis of the three stages showed 2609, 3333, and 170 differentially expressed 
      genes (DEGs) in BG-vs-BA, BG-vs-BA, and BS-vs-BA, respectively. The Gene Ontology 
      (GO) enrichment analysis of DEGs revealed that the regulation of cyclin-dependent 
      protein serine/threonine kinase activity, oxidative phosphorylation, and 
      respiratory chain were significantly enriched. The significant enrichment 
      analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway identified 
      pathways associated with the regulation of death, such as the mammalian target of 
      rapamycin (mTOR) signaling pathway, AMPK signaling pathway, oxidative 
      phosphorylation, and cell cycle. CONCLUSION: The post-reproductive death of S. 
      esculenta was found to be a complex energy steady-state regulation network 
      system. The mTOR acted as an energy receptor and had a key role in regulating 
      energy homeostasis.
FAU - Zhang, Jinyong
AU  - Zhang J
AD  - Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.
AD  - Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao, 266071, China.
AD  - Function Laboratory for Marine Fisheries Science and Food Production Processes, 
      Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266200, 
      China.
FAU - He, Muchun
AU  - He M
AD  - Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of 
      Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
FAU - Xiang, Zilong
AU  - Xiang Z
AD  - College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 
      201306, China.
FAU - Liu, Shufang
AU  - Liu S
AUID- ORCID: 0000-0003-3766-2932
AD  - Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China. 
      liusf@ysfri.ac.cn.
AD  - Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao, 266071, China. liusf@ysfri.ac.cn.
AD  - Function Laboratory for Marine Fisheries Science and Food Production Processes, 
      Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266200, 
      China. liusf@ysfri.ac.cn.
FAU - Zhuang, ZhiMeng
AU  - Zhuang Z
AD  - Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China. 
      zhuangzm@ysfri.ac.cn.
AD  - Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao, 266071, China. zhuangzm@ysfri.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190402
PL  - Korea (South)
TA  - Genes Genomics
JT  - Genes & genomics
JID - 101481027
SB  - IM
MH  - Animals
MH  - Brain/growth & development/*metabolism
MH  - Female
MH  - Gene Regulatory Networks
MH  - *Life Cycle Stages
MH  - *Reproduction
MH  - Sepia/*genetics/growth & development/physiology
MH  - *Transcriptome
OTO - NOTNLM
OT  - DEGs
OT  - Golden cuttlefish
OT  - Rapid post-reproductive death
OT  - Sepia esculenta
OT  - Subpeduncle lobe/olfactory lobe
OT  - Transcriptome
EDAT- 2019/04/04 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/04/04 06:00
PHST- 2018/12/13 00:00 [received]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
AID - 10.1007/s13258-019-00811-z [pii]
AID - 10.1007/s13258-019-00811-z [doi]
PST - ppublish
SO  - Genes Genomics. 2019 Jun;41(6):629-645. doi: 10.1007/s13258-019-00811-z. Epub 
      2019 Apr 2.