PMID- 30941844
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 40
IP  - 11
DP  - 2019 Aug 1
TI  - Distinct and opposite profiles of connectivity during self-reference task and 
      rest in youth at clinical high risk for psychosis.
PG  - 3254-3264
LID - 10.1002/hbm.24595 [doi]
AB  - Self-reference is impaired in psychotic disorders such as schizophrenia, 
      associated with disability, and closely related to characteristic patterns of 
      aberrant brain connectivity. However, at present, it is unclear whether 
      self-reference is impacted in pathogenesis of the disorder. Alterations in 
      connectivity during a self-reference task or resting-state in the psychosis risk 
      (i.e., prodromal) period may yield important clues for biomarker development, as 
      well as for novel treatment targets. This study examined a task-based and 
      resting-state functional magnetic resonance imaging in individuals at clinical 
      high risk (CHR) for psychosis (n = 22) and healthy control unaffected peers 
      (n = 20). The self-reference task comprised three task conditions where subjects 
      were asked if an adjective was relevant to themselves (self), a designated other 
      individual (other), or to evaluate the word's spelling (letter). Connectivity 
      analyses examined medial prefrontal cortex (mPFC) and posterior cingulate cortex 
      (PCC), regions commonly found in conjunction analyses of self-reference, during 
      both the self-reference task and rest. In task connectivity analyses, CHR 
      individuals exhibited decreased mPFC-PCC connectivity when compared to controls. 
      In resting-state analyses, CHR participants showed greater mPFC-PCC connectivity. 
      Taken together, results suggest that psychosis-like alterations in mPFC-PCC 
      connectivity is present prior to psychosis onset across both task and rest.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Damme, Katherine S F
AU  - Damme KSF
AUID- ORCID: 0000-0003-4260-1528
AD  - Department of Psychology, Northwestern University, Evanston, Illinois.
FAU - Pelletier-Baldelli, Andrea
AU  - Pelletier-Baldelli A
AUID- ORCID: 0000-0002-3111-5244
AD  - Department of Psychiatry, UNC-Chapel Hill School of Medicine, Chapel Hill, North 
      Carolina.
FAU - Cowan, Henry R
AU  - Cowan HR
AUID- ORCID: 0000-0001-9891-6903
AD  - Department of Psychology, Northwestern University, Evanston, Illinois.
FAU - Orr, Joseph M
AU  - Orr JM
AUID- ORCID: 0000-0002-6539-339X
AD  - Department of Psychological and Brain Sciences, Texas A&M University, College 
      Station, Texas.
AD  - Texas A&M Institute for Neuroscience, Texas A&M University, College Station, 
      Texas.
FAU - Mittal, Vijay A
AU  - Mittal VA
AUID- ORCID: 0000-0001-9017-5119
AD  - Department of Psychology, Northwestern University, Evanston, Illinois.
AD  - Department of Psychiatry, Northwestern University, Chicago, Illinois.
AD  - Medical Social Sciences, Northwestern University, Chicago, Illinois.
AD  - Institute for Policy Research (IPR), Northwestern University, Chicago, Illinois.
AD  - Institute for Innovations in Developmental Sciences (DevSci), Northwestern 
      University, Evanston, Illinois.
LA  - eng
GR  - MH112545/NH/NIH HHS/United States
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
GR  - T32HD040127/NH/NIH HHS/United States
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - R21MH110374/NH/NIH HHS/United States
GR  - MH094650/NH/NIH HHS/United States
GR  - R21 MH103231/MH/NIMH NIH HHS/United States
GR  - R01s. MH094650/NH/NIH HHS/United States
GR  - MH112545-01/NH/NIH HHS/United States
GR  - T32 HD040127/HD/NICHD NIH HHS/United States
GR  - R21/R33MH103231/NH/NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - MH103231/NH/NIH HHS/United States
GR  - R01 MH094650/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190402
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Brain/*diagnostic imaging
MH  - Female
MH  - Functional Neuroimaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*diagnostic imaging
MH  - Neuropsychological Tests
MH  - Psychotic Disorders/*diagnostic imaging/psychology
MH  - Theory of Mind/*physiology
MH  - Young Adult
PMC - PMC6592773
MID - NIHMS1026342
OTO - NOTNLM
OT  - prodrome
OT  - psychosis
OT  - resting-state
OT  - self-reference
OT  - self-reflection
OT  - theory of mind
EDAT- 2019/04/04 06:00
MHDA- 2020/04/01 06:00
PMCR- 2019/04/02
CRDT- 2019/04/04 06:00
PHST- 2019/01/25 00:00 [received]
PHST- 2019/03/24 00:00 [revised]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
PHST- 2019/04/02 00:00 [pmc-release]
AID - HBM24595 [pii]
AID - 10.1002/hbm.24595 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2019 Aug 1;40(11):3254-3264. doi: 10.1002/hbm.24595. Epub 2019 
      Apr 2.