PMID- 30941944
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20190802
IS  - 2241-6293 (Electronic)
IS  - 1107-0625 (Linking)
VI  - 24
IP  - 1
DP  - 2019 Jan-Feb
TI  - Caspase complex in laryngeal squamous cell carcinoma.
PG  - 1-4
AB  - Caspases (cysteine-aspartic proteases) represent a family of enzymes that modify 
      several functions crucial for cell homeostasis such as inflammation and 
      apoptosis. According to their implication in the apoptotic pathways, caspases are 
      characterized as initiators and executioners, respectively. In the first group 
      have been inserted caspase-2,-8,-9, and -10, whereas caspase-3,-6, and-7 belong 
      to the second category. All of these normal actions of the caspase complex that 
      induce apoptosis are altered in carcinoma progression and establishment. In 
      cancer tissues, programmed cell death is inhibited due to a deregulation in 
      expression of apo- and anti-apoptotic proteins. This genetic imbalance drives the 
      cancer cell to immortalization which reflects the aberrant tissue proliferation. 
      For this reason, caspases and the other apoptotic molecules are considered as 
      important targets for specific targeted therapeutic strategies for enhancing the 
      apoptotic levels inside the malignant tumor cells cores. In the current review we 
      explored the role of caspases deregulation in laryngeal squamous cell carcinoma 
      (LSCC). In malignancies -including LSCC- its deregulation leads the cells to 
      immortalization due to apoptosis inhibition and telomerase overexpression. 
      Caspase-dependent apoptotic rates are decreased in LSCC. For this reason, 
      caspases are considered a very promising target for applying targeted therapeutic 
      strategies in order to enhance apoptosis in the corresponding patients suffering 
      of LSCC.
FAU - Chrysovergis, Aristeidis
AU  - Chrysovergis A
AD  - 1st ENT Dept, Hippocration Hospital, University of Athens, Athens, Greece.
FAU - S Papanikolaou, Vasileios
AU  - S Papanikolaou V
FAU - Tsiambas, Evangelos
AU  - Tsiambas E
FAU - Kikidis, Dimitrios
AU  - Kikidis D
FAU - Maragoudakis, Panagiotis
AU  - Maragoudakis P
FAU - Ragos, Vasileios
AU  - Ragos V
FAU - Kyrodimos, Efthymios
AU  - Kyrodimos E
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - EC 3.4.22.- (Caspases)
MH  - Animals
MH  - *Apoptosis
MH  - Carcinoma, Squamous Cell/*enzymology/*pathology
MH  - Caspases/*metabolism
MH  - Cell Proliferation
MH  - Humans
MH  - Laryngeal Neoplasms/*enzymology/*pathology
MH  - Signal Transduction
EDAT- 2019/04/04 06:00
MHDA- 2019/08/03 06:00
CRDT- 2019/04/04 06:00
PHST- 2019/04/04 06:00 [entrez]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PST - ppublish
SO  - J BUON. 2019 Jan-Feb;24(1):1-4.