PMID- 30942466
OWN - NLM
STAT- MEDLINE
DCOM- 20190801
LR  - 20200225
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 19
IP  - 5
DP  - 2019 May
TI  - Prenatal nicotine exposure induces depression‑like behavior in adolescent female 
      rats via modulating neurosteroid in the hippocampus.
PG  - 4185-4194
LID - 10.3892/mmr.2019.10105 [doi]
AB  - Prenatal nicotine exposure (PNE) is closely related to depression in offspring. 
      However, the underlying mechanism is still unclear. We hypothesized that 
      neurosteroid in the hippocampus may mediate PNE‑induced depression‑like 
      behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant rats 
      twice daily from gestational day (GD) 9 to 20. In adolescent offspring, PNE 
      significantly increased immobility time and decreased the sucrose preference in 
      female rats. The numbers of hippocampal neurons declined in the CA3 and DG 
      regions. Steroidogenic acute regulatory protein (StAR) expression was suppressed 
      in female rats. In fetal offspring, the neuronal numbers of CA3 regions in PNE 
      female fetal hippocampal were significantly decreased, accompanied by the 
      enhanced content of corticosterone and StAR expression. These data indicated that 
      PNE induced depression‑like behavior in adolescent female rats via the regulation 
      of neurosteroid levels in the hippocampus.
FAU - Zhang, Chong
AU  - Zhang C
AD  - Department of Pharmacy, Xiangyang No. 1 People's Hospital, Hubei University of 
      Medicine, Xiangyang, Hubei 441000, P.R. China.
FAU - Fan, Si-Jing
AU  - Fan SJ
AD  - Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 
      434023, P.R. China.
FAU - Sun, An-Bang
AU  - Sun AB
AD  - Laboratory of Neuronal and Brain Disease Modulation, Yangtze University, 
      Jingzhou, Hubei 434023, P.R. China.
FAU - Liu, Zhen-Zhen
AU  - Liu ZZ
AD  - Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 
      434023, P.R. China.
FAU - Liu, Lian
AU  - Liu L
AD  - Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 
      434023, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190329
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Biomarkers)
RN  - 0 (Neurotransmitter Agents)
RN  - 6M3C89ZY6R (Nicotine)
MH  - Animals
MH  - Behavior, Animal
MH  - Biomarkers
MH  - Depressive Disorder/*etiology/psychology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression
MH  - Hippocampus/*metabolism/pathology/*physiopathology
MH  - Maternal Exposure/*adverse effects
MH  - Neurotransmitter Agents/*metabolism
MH  - Nicotine/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
PMC - PMC6471439
EDAT- 2019/04/04 06:00
MHDA- 2019/08/02 06:00
PMCR- 2019/03/29
CRDT- 2019/04/04 06:00
PHST- 2018/07/30 00:00 [received]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2019/08/02 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
PHST- 2019/03/29 00:00 [pmc-release]
AID - mmr-19-05-4185 [pii]
AID - 10.3892/mmr.2019.10105 [doi]
PST - ppublish
SO  - Mol Med Rep. 2019 May;19(5):4185-4194. doi: 10.3892/mmr.2019.10105. Epub 2019 Mar 
      29.