PMID- 30942958
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20200107
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 13
IP  - 6
DP  - 2019 Jun
TI  - Carotid intima-media thickness in chronic obstructive pulmonary disease and 
      survival: A multicenter prospective study.
PG  - 391-399
LID - 10.1111/crj.13024 [doi]
AB  - INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is associated with 
      increased cardiovascular morbidity and mortality. Carotid intima-media thickness 
      (CIMT) is a noninvasive method assessing atherosclerosis. OBJECTIVE: It was aimed 
      to determine relationship and survival between COPD and CIMT. METHODS: CIMT was 
      measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 
      centers. Patients were followed-up for 2 years. RESULTS: There were 610 patients 
      who completed the study. There were 200 patients CIMT with <0.78 mm (group 1), 
      and 410 with CIMT >/= 0.78 mm (group 2). There was a significant difference at the 
      parameters of age, gender, smoking load, biomass exposure, GOLD groups and degree 
      of airway obstruction (FEV1) between groups 1 and 2. Our results revealed 
      positive correlations between mean CIMT and age, smoking load (pack-years), 
      biomass exposure (years), exacerbation rate (last year), duration of hypertension 
      (years) and cholesterol level; negative correlations between CIMT and FEV(1) 
      (P < 0.05). According to logistic regression model, compared with group A, risk 
      of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in 
      group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level 
      (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the 
      patients with frequent exacerbation (P < 0.05). The mean survival time was 
      slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05). 
      CONCLUSION: This study is the first regarding CIMT with combined GOLD assessment 
      groups. It has revealed important findings supporting the increase in 
      atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid 
      artery in COPD patients at severe stages.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Gulbas, Gazi
AU  - Gulbas G
AD  - Department of Pulmonary Medicine, Turgut Ozal Research Center, Inonu University, 
      Malatya, Turkey.
FAU - Turan, Onur
AU  - Turan O
AUID- ORCID: 0000-0001-6320-0470
AD  - Department of Pulmonary Medicine, Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Sarioglu, Nurhan
AU  - Sarioglu N
AD  - Department of Pulmonary Medicine, Balikesir University, Balikesir, Turkey.
FAU - Diken, Ozlem Ercen
AU  - Diken OE
AUID- ORCID: 0000-0001-8388-9500
AD  - Department of Pulmonary Medicine, Hitit University, Corum, Turkey.
FAU - Ogan, Nalan
AU  - Ogan N
AUID- ORCID: 0000-0001-5232-3803
AD  - Department of Pulmonary Medicine, Ufuk University, Ankara, Turkey.
FAU - Ekbic Kadioglu, Esra
AU  - Ekbic Kadioglu E
AD  - Department of Pulmonary Medicine, Erzurum Training and Research Hospital, 
      Erzurum, Turkey.
FAU - Kurtipek, Ercan
AU  - Kurtipek E
AD  - Department of Pulmonary Medicine, Konya Training and Research Hospital, Konya, 
      Turkey.
FAU - Bozkus, Fulsen
AU  - Bozkus F
AUID- ORCID: 0000-0002-6498-4390
AD  - Department of Pulmonary Medicine, Sutcu Imam University, K. Maras, Turkey.
FAU - Yilmaz Demirci, Nilgun
AU  - Yilmaz Demirci N
AUID- ORCID: 0000-0001-6160-3778
AD  - Department of Pulmonary Medicine, Gazi University, Ankara, Turkey.
FAU - Coskun Beyan, Ayse
AU  - Coskun Beyan A
AD  - Department of Pulmonary Medicine, Dokuz Eylul University, Izmir, Turkey.
FAU - Mutlu, Levent Cem
AU  - Mutlu LC
AD  - Department of Pulmonary Medicine, Namik Kemal University, Tekirdag, Turkey.
FAU - Sahin Duyar, Sezgi
AU  - Sahin Duyar S
AD  - Department of Pulmonary Medicine, Beypazari State Hospital, Ankara, Turkey.
FAU - Deniz, Sami
AU  - Deniz S
AUID- ORCID: 0000-0002-8328-295X
AD  - Department of Pulmonary Medicine, Didim State Hospital, Mugla, Turkey.
FAU - Fazlioglu, Nevin
AU  - Fazlioglu N
AD  - Department of Pulmonary Medicine, Acibadem Hospital, Kayseri, Turkey.
FAU - Sengul, Aysun
AU  - Sengul A
AD  - Derince Training and Research Hospital, Kocaeli, Turkey.
FAU - Tanriverdi, Hakan
AU  - Tanriverdi H
AD  - Department of Pulmonary Medicine, Bulent Ecevit University, Zonguldak, Turkey.
FAU - Okutan, Oguzhan
AU  - Okutan O
AD  - Department of Pulmonary Medicine, GATA, Training and Research Hospital, Istanbul.
FAU - Turan, Pakize Ayse
AU  - Turan PA
AD  - Department of Pulmonary Medicine, Menemen State Hospital, Izmir, Turkey.
FAU - Inonu, Handan
AU  - Inonu H
AD  - Department of Pulmonary Medicine, Gazi Osman Pasa University, Tokat, Turkey.
FAU - Ortakoylu, Mediha Gonenc
AU  - Ortakoylu MG
AD  - Department of Pulmonary Medicine, Yedikule Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Lakadamyali, Huseyin
AU  - Lakadamyali H
AD  - Department of Pulmonary Medicine, Baskent University, Alanya, Turkey.
FAU - Kivanc, Tulay
AU  - Kivanc T
AD  - Department of Pulmonary Medicine, Baskent University, Konya, Turkey.
FAU - Atli, Ozgur
AU  - Atli O
AD  - Department of Pulmonary Medicine, Diyarbakir State Hospital, Diyarbakir, Turkey.
FAU - Ozdemir, Ozer
AU  - Ozdemir O
AD  - Egepol Hospital, Izmir, Turkey.
FAU - Filiz Kosar, A
AU  - Filiz Kosar A
AD  - Department of Pulmonary Medicine, Saglik Bilimleri University, Istanbul, Turkey.
FAU - Mirici, Arzu
AU  - Mirici A
AD  - Department of Pulmonary Medicine, 18 Mart University, Canakkale, Turkey.
FAU - Suerdem, Mecit
AU  - Suerdem M
AD  - Department of Pulmonary Medicine, Selcuk University, Konya, Turkey.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20190508
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
SB  - IM
MH  - Aged
MH  - Atherosclerosis/*diagnostic imaging/etiology/mortality
MH  - Carotid Intima-Media Thickness
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/complications/diagnostic 
      imaging/*mortality
MH  - Risk Assessment
MH  - Survival Analysis
OTO - NOTNLM
OT  - COPD
OT  - carotid intima-media
OT  - exacerbation
OT  - survival
EDAT- 2019/04/04 06:00
MHDA- 2020/01/08 06:00
CRDT- 2019/04/04 06:00
PHST- 2018/10/08 00:00 [received]
PHST- 2019/03/19 00:00 [revised]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2020/01/08 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
AID - 10.1111/crj.13024 [doi]
PST - ppublish
SO  - Clin Respir J. 2019 Jun;13(6):391-399. doi: 10.1111/crj.13024. Epub 2019 May 8.