PMID- 30943491
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 179
IP  - 3
DP  - 2019
TI  - Epicutaneous Exposure to Peanut Oil Induces Systemic and Pulmonary Allergic 
      Reaction in Mice.
PG  - 187-191
LID - 10.1159/000497382 [doi]
AB  - BACKGROUND: The prevalence of peanut allergy (PA) is constantly on the rise. 
      Atopic dermatitis (AD) is a major risk factor for developing food allergy. Some 
      bath oils and skin creams used for treating AD contain peanut oil, and it has 
      been suggested that exposure to peanut allergens through a disrupted skin barrier 
      is a potential cause of PA. Our aim was to investigate whether application of 
      peanut oil to irritated skin causes a systemic or respiratory allergic response 
      to peanuts in an animal model. METHODS: BALB/c mice underwent epicutaneous 
      sensitization with either peanut oil (PM, n = 9) or phosphate buffered solution 
      (controls, n = 9) daily for 5 consecutive days. Ten days after the last exposure 
      the mice were challenged with intranasal peanut protein for 5 consecutive days. 
      Bronchial alveolar lavage fluid was collected for cellular studies and 
      measurement of cytokine levels. Sera were collected for immunoglobulin E (IgE) 
      measurement. RESULTS: Epicutaneous peanut oil sensitization increased leukocyte 
      and eosinophil counts and interleukin-13 levels (p = 0.003, p = 0.0006 and p = 
      0.03, respectively), in addition to increasing total serum IgE (p = 0.03). 
      CONCLUSIONS: The results suggest that topical application of peanut oil may play 
      a role in the etiology of PA.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Benor, Shira
AU  - Benor S
AD  - Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel, shirabe@tlvmc.gov.il.
FAU - Shani, Nir
AU  - Shani N
AD  - The Microsurgery and Plastic Surgery Laboratory, The Plastic Surgery Department, 
      Tel-Aviv Medical Center, Tel Aviv, Israel.
FAU - Etkin, Sara
AU  - Etkin S
AD  - Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Bondar, Ekaterina
AU  - Bondar E
AD  - Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Kivity, Shmuel
AU  - Kivity S
AD  - Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Langier, Sheila
AU  - Langier S
AD  - Allergy and Immunology Unit, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20190403
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Cytokines)
RN  - 0 (Il4 protein, mouse)
RN  - 0 (Interleukin-13)
RN  - 0 (Peanut Oil)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - Administration, Cutaneous
MH  - Allergens/*administration & dosage
MH  - Animals
MH  - Antigens, Plant/*administration & dosage
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cytokines/immunology
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Interleukin-13/immunology
MH  - Interleukin-4/immunology
MH  - Leukocyte Count
MH  - Lung/drug effects/immunology
MH  - Mice, Inbred BALB C
MH  - *Peanut Hypersensitivity/blood/immunology
MH  - Peanut Oil/*administration & dosage
MH  - *Respiratory Hypersensitivity/blood/immunology
OTO - NOTNLM
OT  - Asthma
OT  - Atopic dermatitis
OT  - Epicutaneous sensitization
OT  - Peanut allergy
OT  - Peanut oil
EDAT- 2019/04/04 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/04/04 06:00
PHST- 2018/11/01 00:00 [received]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/04/04 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/04/04 06:00 [entrez]
AID - 000497382 [pii]
AID - 10.1159/000497382 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2019;179(3):187-191. doi: 10.1159/000497382. Epub 2019 
      Apr 3.